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• W3003309096 abstract "Summary Systemic sclerosis (SSc) is a complex, heterogeneous autoimmune connective tissue disease. Autologous hematopoietic stem-cell transplantation (AHSCT) has emerged as a valuable treatment option for rapidly progressive diffuse cutaneous SSc (dcSSc) patients, and thus far is the only treatment that has been shown to have a long-term clinical benefit. AHSCT is thought to reintroduce immune homeostasis through elimination of pathogenic self-reactive immune cells and reconstitution of a new, tolerant immune system. However, the mechanism of action underlying this reset to tolerance remains largely unknown. In this study we review the immune mechanisms underlying AHSCT for SSc, with a focus on the role of the innate immune cells, including monocytes and natural killer (NK) cells, in restoring immune balance after AHSCT." @default.
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• W3003309096 date "2020-02-17" @default.
• W3003309096 modified "2023-10-03" @default.
• W3003309096 title "The role of innate immune cells in systemic sclerosis in the context of autologous hematopoietic stem cell transplantation" @default.
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• W3003309096 doi "https://doi.org/10.1111/cei.13419" @default.
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