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- W3003311203 abstract "Transcription initiation and RNA processing govern gene expression and enable bacterial adaptation by reshaping the RNA landscape. The aim of this study was to simultaneously observe these two fundamental processes in a transcriptome responding to an environmental signal. A controlled σ E system in E. coli was coupled to our previously described tagRNA-seq method to yield process kinetics information. Changes in transcription initiation frequencies (TIF) and RNA processing frequencies (PF) were followed using 5′ RNA tags. Changes in TIF showed a binary increased/decreased pattern that alternated between transcriptionally activated and repressed promoters, providing the bacterial population with transcriptional oscillation. PF variation fell into three categories of cleavage activity: (i) constant and independent of RNA levels, (ii) increased once RNA has accumulated, and (iii) positively correlated to changes in TIF. This work provides a comprehensive and dynamic view of major events leading to transcriptomic reshaping during bacterial adaptation. It unveils an interplay between transcription initiation and the activity of specific RNA cleavage sites. This study utilized a well-known genetic system to analyze fundamental processes and can serve as a blueprint for comprehensive studies that exploit the RNA metabolism to decipher and understand bacterial gene expression control." @default.
- W3003311203 created "2020-02-07" @default.
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- W3003311203 date "2020-01-28" @default.
- W3003311203 modified "2023-10-12" @default.
- W3003311203 title "Dynamic insights on transcription initiation and RNA processing during bacterial adaptation" @default.
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- W3003311203 doi "https://doi.org/10.1261/rna.073288.119" @default.
- W3003311203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7075262" @default.
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