FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003324147> ?p ?o ?g. }

• W3003324147 endingPage "104" @default.
• W3003324147 startingPage "104" @default.
• W3003324147 abstract "Hydrochlorothiazide (HCT), a Biopharmaceutical Classification System (BCS) class IV drug, is characterized by low solubility and permeability, that negatively affect its oral bioavailability, reducing its therapeutic efficacy. The combined use of cyclodextrins (CDs) and nanoclays (NCs) recently proved to be a successful strategy in developing delivery systems able to merge the potential benefits of both carriers. In this work, several binary systems of CDs or NCs with the drug were obtained, using different drug:carrier ratios and preparation techniques, and characterized in solution and in solid state, to properly select the most effective system and preparation method. Then, the best CD (RAMEB) and NC (sepiolite), at the best drug:carrier ratio, was selected for preparation of the ternary system by co-evaporation and emerged as the most effective preparation method. The combined presence of RAMEB and sepiolite gave rise to a synergistic improvement of drug dissolution properties, with a two-fold increase in the amount of drug dissolved as compared with the corresponding HCT-RAMEB system, resulting in an approximately 12-fold increase in drug solubility as compared with the drug alone. The ternary system that was co-evaporated was then selected for a tablet formulation. The obtained tablets were fully characterized for technological properties and clearly revealed a better drug dissolution performance than the commercial reference tablet (Esidrex)." @default.
• W3003324147 created "2020-02-07" @default.
• W3003324147 creator A5010948488 @default.
• W3003324147 creator A5042287581 @default.
• W3003324147 creator A5050895361 @default.
• W3003324147 creator A5056817675 @default.
• W3003324147 creator A5066280195 @default.
• W3003324147 creator A5075961462 @default.
• W3003324147 date "2020-01-28" @default.
• W3003324147 modified "2023-10-14" @default.
• W3003324147 title "Tablets of “Hydrochlorothiazide in Cyclodextrin in Nanoclay”: A New Nanohybrid System with Enhanced Dissolution Properties" @default.
• W3003324147 cites W1495136860 @default.
• W3003324147 cites W1498305210 @default.
• W3003324147 cites W1541034768 @default.
• W3003324147 cites W1965970894 @default.
• W3003324147 cites W1987792264 @default.
• W3003324147 cites W1993850123 @default.
• W3003324147 cites W1996481160 @default.
• W3003324147 cites W1997838676 @default.
• W3003324147 cites W2001570423 @default.
• W3003324147 cites W2004036804 @default.
• W3003324147 cites W2021559377 @default.
• W3003324147 cites W2031676331 @default.
• W3003324147 cites W2035034315 @default.
• W3003324147 cites W2041406898 @default.
• W3003324147 cites W2044932064 @default.
• W3003324147 cites W2052417468 @default.
• W3003324147 cites W2080440680 @default.
• W3003324147 cites W2088828170 @default.
• W3003324147 cites W2191849897 @default.
• W3003324147 cites W2359759717 @default.
• W3003324147 cites W2589090401 @default.
• W3003324147 cites W2590373290 @default.
• W3003324147 cites W2596582956 @default.
• W3003324147 cites W2621762414 @default.
• W3003324147 cites W2771923364 @default.
• W3003324147 cites W2800612483 @default.
• W3003324147 cites W2800959783 @default.
• W3003324147 cites W2922847814 @default.
• W3003324147 cites W2973915111 @default.
• W3003324147 cites W301531594 @default.
• W3003324147 cites W4211053799 @default.
• W3003324147 cites W2615669703 @default.
• W3003324147 doi "https://doi.org/10.3390/pharmaceutics12020104" @default.
• W3003324147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7076548" @default.
• W3003324147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32013051" @default.
• W3003324147 hasPublicationYear "2020" @default.
• W3003324147 type Work @default.
• W3003324147 sameAs 3003324147 @default.
• W3003324147 citedByCount "9" @default.
• W3003324147 countsByYear W30033241472020 @default.
• W3003324147 countsByYear W30033241472021 @default.
• W3003324147 countsByYear W30033241472022 @default.
• W3003324147 countsByYear W30033241472023 @default.
• W3003324147 crossrefType "journal-article" @default.
• W3003324147 hasAuthorship W3003324147A5010948488 @default.
• W3003324147 hasAuthorship W3003324147A5042287581 @default.
• W3003324147 hasAuthorship W3003324147A5050895361 @default.
• W3003324147 hasAuthorship W3003324147A5056817675 @default.
• W3003324147 hasAuthorship W3003324147A5066280195 @default.
• W3003324147 hasAuthorship W3003324147A5075961462 @default.
• W3003324147 hasBestOaLocation W30033241471 @default.
• W3003324147 hasConcept C126838900 @default.
• W3003324147 hasConcept C127413603 @default.
• W3003324147 hasConcept C13965031 @default.
• W3003324147 hasConcept C147789679 @default.
• W3003324147 hasConcept C155574463 @default.
• W3003324147 hasConcept C178790620 @default.
• W3003324147 hasConcept C181389837 @default.
• W3003324147 hasConcept C185592680 @default.
• W3003324147 hasConcept C187530423 @default.
• W3003324147 hasConcept C192562407 @default.
• W3003324147 hasConcept C2779433975 @default.
• W3003324147 hasConcept C2779820397 @default.
• W3003324147 hasConcept C2780035454 @default.
• W3003324147 hasConcept C2780361556 @default.
• W3003324147 hasConcept C2781047461 @default.
• W3003324147 hasConcept C42360764 @default.
• W3003324147 hasConcept C43617362 @default.
• W3003324147 hasConcept C54355233 @default.
• W3003324147 hasConcept C71924100 @default.
• W3003324147 hasConcept C77281830 @default.
• W3003324147 hasConcept C84393581 @default.
• W3003324147 hasConcept C86178769 @default.
• W3003324147 hasConcept C86803240 @default.
• W3003324147 hasConcept C88380143 @default.
• W3003324147 hasConcept C98274493 @default.
• W3003324147 hasConceptScore W3003324147C126838900 @default.
• W3003324147 hasConceptScore W3003324147C127413603 @default.
• W3003324147 hasConceptScore W3003324147C13965031 @default.
• W3003324147 hasConceptScore W3003324147C147789679 @default.
• W3003324147 hasConceptScore W3003324147C155574463 @default.
• W3003324147 hasConceptScore W3003324147C178790620 @default.
• W3003324147 hasConceptScore W3003324147C181389837 @default.
• W3003324147 hasConceptScore W3003324147C185592680 @default.
• W3003324147 hasConceptScore W3003324147C187530423 @default.
• W3003324147 hasConceptScore W3003324147C192562407 @default.
• W3003324147 hasConceptScore W3003324147C2779433975 @default.

• next