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- W3003325507 abstract "Abstract Many parasitic infections stimulate antibody responses in their mammalian hosts. The ability of these antibodies to protect against disease varies markedly. Research has revealed that functional properties of antibodies determine their role in protection against parasites. Investigations of antibodies against Plasmodium spp. have demonstrated a variety of functional activities, ranging from invasion inhibition and parasite growth inhibition to antibody‐dependent cellular phagocytosis and antibody‐dependent cellular cytotoxicity. These activities have been demonstrated with a large variety of parasite molecules at multiple life cycle stages, highlighting the importance of functional antibody responses in malaria. Other parasitic infections have not yet been investigated in similar detail, but these mechanisms are likely to operate in nonmalarial parasitic infections as well. In this report, we review data on the role of functional antibody responses in protection from parasitic infections, highlighting discoveries in malaria, a parasite for which our knowledge base is the most advanced." @default.
- W3003325507 created "2020-02-07" @default.
- W3003325507 creator A5028009379 @default.
- W3003325507 creator A5049265849 @default.
- W3003325507 creator A5059269078 @default.
- W3003325507 date "2020-02-24" @default.
- W3003325507 modified "2023-10-16" @default.
- W3003325507 title "Antibody effector functions in malaria and other parasitic diseases: a few needles and many haystacks" @default.
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- W3003325507 doi "https://doi.org/10.1111/imcb.12320" @default.
- W3003325507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32003072" @default.
- W3003325507 hasPublicationYear "2020" @default.
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