FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003348449> ?p ?o ?g. }

• W3003348449 endingPage "1029" @default.
• W3003348449 startingPage "1020" @default.
• W3003348449 abstract "Abstract MicroRNAs (miRNAs) have emerged as critical regulators of neuronal survival during cerebral ischaemia/reperfusion injury. Accumulating evidence has shown that miR‐199a‐5p plays a crucial role in regulating apoptosis and survival in various cell types. However, whether miR‐199a is involved in regulating neuronal survival during cerebral ischaemia/reperfusion injury remains unknown. In this study, we aimed to explore the biological role of miR‐199a‐5p in regulating neuronal injury induced by oxygen‐glucose deprivation/reoxygenation (OGD/R), an in vitro cellular model of cerebral ischaemia and reperfusion injury. We found that miR‐199a‐5p expression was significantly altered in neurons in response to OGD/R treatment. Overexpression of miR‐199a‐5p facilitated OGD/R‐induced apoptosis and reactive oxygen species (ROS) production, whereas miR‐199a‐5p inhibition alleviated OGD/R‐induced apoptosis and ROS production. Notably, our results identified Brahma‐related gene 1 (Brg1) as a target gene of miR‐199a‐5p. Moreover, inhibition of miR‐199a‐5p promoted the activation of nuclear factor‐erythroid‐2‐related factor‐2 (Nrf2)/heme oxygenase‐1 (HO‐1) signalling via targeting Brg1. However, silencing of Brg1 markedly reversed the miR‐199a‐5p inhibition‐mediated neuroprotective effect. Taken together, our results suggest that downregulation of miR‐199a‐5p protects neurons from OGD/R‐induced neuronal injury through upregulating Brg1 to activate Nrf2/HO‐1 signalling. The miR‐199a‐5p/Brg1/Nrf2/HO‐1 regulation axis may play an important role in regulating neuronal survival during cerebral ischaemic/reperfusion injury in vivo." @default.
• W3003348449 created "2020-02-07" @default.
• W3003348449 creator A5018775744 @default.
• W3003348449 creator A5036380789 @default.
• W3003348449 creator A5062906378 @default.
• W3003348449 creator A5079609871 @default.
• W3003348449 creator A5081844561 @default.
• W3003348449 date "2020-02-10" @default.
• W3003348449 modified "2023-09-26" @default.
• W3003348449 title "Inhibition of microRNA‐199a‐5p ameliorates oxygen‐glucose deprivation/reoxygenation‐induced apoptosis and oxidative stress in HT22 neurons by targeting Brg1 to activate Nrf2/HO‐1 signalling" @default.
• W3003348449 cites W144423133 @default.
• W3003348449 cites W1647004417 @default.
• W3003348449 cites W1970552047 @default.
• W3003348449 cites W2003724153 @default.
• W3003348449 cites W2010740759 @default.
• W3003348449 cites W2010972046 @default.
• W3003348449 cites W2024419054 @default.
• W3003348449 cites W2029276286 @default.
• W3003348449 cites W2032278760 @default.
• W3003348449 cites W2034374426 @default.
• W3003348449 cites W2037906258 @default.
• W3003348449 cites W2038528121 @default.
• W3003348449 cites W2040851473 @default.
• W3003348449 cites W2047499088 @default.
• W3003348449 cites W2057599755 @default.
• W3003348449 cites W2059851734 @default.
• W3003348449 cites W2068067927 @default.
• W3003348449 cites W2068780254 @default.
• W3003348449 cites W2074695498 @default.
• W3003348449 cites W2088892416 @default.
• W3003348449 cites W2102381606 @default.
• W3003348449 cites W2138625851 @default.
• W3003348449 cites W2170945707 @default.
• W3003348449 cites W2171165037 @default.
• W3003348449 cites W2252938521 @default.
• W3003348449 cites W2288807719 @default.
• W3003348449 cites W2295616444 @default.
• W3003348449 cites W2301476344 @default.
• W3003348449 cites W2327005315 @default.
• W3003348449 cites W2327433548 @default.
• W3003348449 cites W2516271526 @default.
• W3003348449 cites W2620692477 @default.
• W3003348449 cites W2686488655 @default.
• W3003348449 cites W2739697505 @default.
• W3003348449 cites W2740301936 @default.
• W3003348449 cites W2760941624 @default.
• W3003348449 cites W2767261781 @default.
• W3003348449 cites W2768061693 @default.
• W3003348449 cites W2768932025 @default.
• W3003348449 cites W2775112683 @default.
• W3003348449 cites W2780389061 @default.
• W3003348449 cites W2782650251 @default.
• W3003348449 cites W2789297171 @default.
• W3003348449 cites W2799684183 @default.
• W3003348449 cites W2806208386 @default.
• W3003348449 cites W315812650 @default.
• W3003348449 doi "https://doi.org/10.1111/1440-1681.13265" @default.
• W3003348449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31990992" @default.
• W3003348449 hasPublicationYear "2020" @default.
• W3003348449 type Work @default.
• W3003348449 sameAs 3003348449 @default.
• W3003348449 citedByCount "15" @default.
• W3003348449 countsByYear W30033484492020 @default.
• W3003348449 countsByYear W30033484492021 @default.
• W3003348449 countsByYear W30033484492022 @default.
• W3003348449 countsByYear W30033484492023 @default.
• W3003348449 crossrefType "journal-article" @default.
• W3003348449 hasAuthorship W3003348449A5018775744 @default.
• W3003348449 hasAuthorship W3003348449A5036380789 @default.
• W3003348449 hasAuthorship W3003348449A5062906378 @default.
• W3003348449 hasAuthorship W3003348449A5079609871 @default.
• W3003348449 hasAuthorship W3003348449A5081844561 @default.
• W3003348449 hasConcept C104317684 @default.
• W3003348449 hasConcept C119056186 @default.
• W3003348449 hasConcept C126322002 @default.
• W3003348449 hasConcept C127561419 @default.
• W3003348449 hasConcept C145059251 @default.
• W3003348449 hasConcept C185592680 @default.
• W3003348449 hasConcept C190283241 @default.
• W3003348449 hasConcept C25498285 @default.
• W3003348449 hasConcept C2776151105 @default.
• W3003348449 hasConcept C2780114680 @default.
• W3003348449 hasConcept C48349386 @default.
• W3003348449 hasConcept C541997718 @default.
• W3003348449 hasConcept C55493867 @default.
• W3003348449 hasConcept C71924100 @default.
• W3003348449 hasConcept C86803240 @default.
• W3003348449 hasConcept C95444343 @default.
• W3003348449 hasConcept C98274493 @default.
• W3003348449 hasConceptScore W3003348449C104317684 @default.
• W3003348449 hasConceptScore W3003348449C119056186 @default.
• W3003348449 hasConceptScore W3003348449C126322002 @default.
• W3003348449 hasConceptScore W3003348449C127561419 @default.
• W3003348449 hasConceptScore W3003348449C145059251 @default.
• W3003348449 hasConceptScore W3003348449C185592680 @default.
• W3003348449 hasConceptScore W3003348449C190283241 @default.
• W3003348449 hasConceptScore W3003348449C25498285 @default.
• W3003348449 hasConceptScore W3003348449C2776151105 @default.

• next