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- W3003395627 abstract "Abstract Metronidazole was until recently used as a first-line treatment for potentially life-threatening Clostridioides difficile (CD) infection. Although cases of metronidazole resistance have been documented, no clear mechanism for metronidazole resistance or a role for plasmids in antimicrobial resistance has been described for CD. Here, we report genome sequences of seven susceptible and sixteen resistant CD isolates from human and animal sources, including isolates from a patient with recurrent CD infection by a PCR ribotype (RT) 020 strain, which developed resistance to metronidazole over the course of treatment (minimal inhibitory concentration [MIC] = 8 mg L −1 ). Metronidazole resistance correlates with the presence of a 7-kb plasmid, pCD-METRO. pCD-METRO is present in toxigenic and non-toxigenic resistant ( n = 23), but not susceptible ( n = 563), isolates from multiple countries. Introduction of a pCD-METRO-derived vector into a susceptible strain increases the MIC 25-fold. Our finding of plasmid-mediated resistance can impact diagnostics and treatment of CD infections." @default.
- W3003395627 created "2020-02-07" @default.
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- W3003395627 date "2020-01-30" @default.
- W3003395627 modified "2023-10-10" @default.
- W3003395627 title "Plasmid-mediated metronidazole resistance in Clostridioides difficile" @default.
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- W3003395627 doi "https://doi.org/10.1038/s41467-020-14382-1" @default.
- W3003395627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6992631" @default.
- W3003395627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32001686" @default.
- W3003395627 hasPublicationYear "2020" @default.
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