Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003449791> ?p ?o ?g. }
- W3003449791 abstract "The mainstay treatment of pulmonary disorders lies around the direct drug targeting to the lungs using a nebulizer, metered-dose inhaler, or dry powder inhaler. Only few inhalers are available in the market that could be used for inhalational drug delivery in rodents. However, the available rodent inhalers invariably require high cost and maintenance, which limits their use at laboratory scale. The present work, therefore, was undertaken to develop a simple, reliable, and cost-effective nose-only inhalation chamber with holding capacity of three mice at a time. The nebulized air passes directly and continuously from the central chamber to mouthpiece and maintains an aerosol cloud for rodents to inhale. Laser diffraction analysis indicated volume mean diameter of 4.02 ± 0.30 μm, and the next-generation impactor studies, however, revealed mean mass aerodynamic diameter of 3.40 ± 0.27 μm, respectively. An amount of 2.05 ± 0.20 mg of voriconazole (VRC) was available for inhalation at each delivery port of the inhaler. In vivo studies indicated the deposition of 76.12 ± 19.50 μg of VRC in the mice lungs when nebulized for a period of 20 min. Overall, the developed nose-only inhalation chamber offers a reliable means of generating aerosols and successfully exposing mice to nebulization." @default.
- W3003449791 created "2020-02-07" @default.
- W3003449791 creator A5009712989 @default.
- W3003449791 creator A5034902895 @default.
- W3003449791 creator A5047025432 @default.
- W3003449791 creator A5061002569 @default.
- W3003449791 creator A5084029971 @default.
- W3003449791 date "2020-01-27" @default.
- W3003449791 modified "2023-10-12" @default.
- W3003449791 title "An Efficient and Cost-Effective Nose-Only Inhalational Chamber for Rodents: Design, Optimization and Validation" @default.
- W3003449791 cites W1519480055 @default.
- W3003449791 cites W1894297117 @default.
- W3003449791 cites W1975069901 @default.
- W3003449791 cites W1982627646 @default.
- W3003449791 cites W1987695176 @default.
- W3003449791 cites W1996344991 @default.
- W3003449791 cites W2009486617 @default.
- W3003449791 cites W2018282990 @default.
- W3003449791 cites W2022508295 @default.
- W3003449791 cites W2026817742 @default.
- W3003449791 cites W2029616918 @default.
- W3003449791 cites W2067701526 @default.
- W3003449791 cites W2079014443 @default.
- W3003449791 cites W2084909154 @default.
- W3003449791 cites W2086630791 @default.
- W3003449791 cites W2099965020 @default.
- W3003449791 cites W2102440762 @default.
- W3003449791 cites W2127082223 @default.
- W3003449791 cites W2131224842 @default.
- W3003449791 cites W2139705562 @default.
- W3003449791 cites W2141859758 @default.
- W3003449791 cites W2157782849 @default.
- W3003449791 cites W2168728308 @default.
- W3003449791 cites W2325169532 @default.
- W3003449791 cites W2408770464 @default.
- W3003449791 cites W2571519750 @default.
- W3003449791 cites W2741992167 @default.
- W3003449791 cites W2744037452 @default.
- W3003449791 cites W2770157469 @default.
- W3003449791 cites W2883728212 @default.
- W3003449791 cites W2906746769 @default.
- W3003449791 cites W2915411550 @default.
- W3003449791 cites W2940248033 @default.
- W3003449791 cites W3007901032 @default.
- W3003449791 doi "https://doi.org/10.1208/s12249-019-1608-4" @default.
- W3003449791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31989357" @default.
- W3003449791 hasPublicationYear "2020" @default.
- W3003449791 type Work @default.
- W3003449791 sameAs 3003449791 @default.
- W3003449791 citedByCount "5" @default.
- W3003449791 countsByYear W30034497912021 @default.
- W3003449791 countsByYear W30034497912022 @default.
- W3003449791 countsByYear W30034497912023 @default.
- W3003449791 crossrefType "journal-article" @default.
- W3003449791 hasAuthorship W3003449791A5009712989 @default.
- W3003449791 hasAuthorship W3003449791A5034902895 @default.
- W3003449791 hasAuthorship W3003449791A5047025432 @default.
- W3003449791 hasAuthorship W3003449791A5061002569 @default.
- W3003449791 hasAuthorship W3003449791A5084029971 @default.
- W3003449791 hasBestOaLocation W30034497912 @default.
- W3003449791 hasConcept C126322002 @default.
- W3003449791 hasConcept C136229726 @default.
- W3003449791 hasConcept C171250308 @default.
- W3003449791 hasConcept C192562407 @default.
- W3003449791 hasConcept C199343813 @default.
- W3003449791 hasConcept C2776042228 @default.
- W3003449791 hasConcept C2776954882 @default.
- W3003449791 hasConcept C2777419714 @default.
- W3003449791 hasConcept C2779820397 @default.
- W3003449791 hasConcept C2780261241 @default.
- W3003449791 hasConcept C2780352487 @default.
- W3003449791 hasConcept C2780667556 @default.
- W3003449791 hasConcept C2780955776 @default.
- W3003449791 hasConcept C42219234 @default.
- W3003449791 hasConcept C71924100 @default.
- W3003449791 hasConceptScore W3003449791C126322002 @default.
- W3003449791 hasConceptScore W3003449791C136229726 @default.
- W3003449791 hasConceptScore W3003449791C171250308 @default.
- W3003449791 hasConceptScore W3003449791C192562407 @default.
- W3003449791 hasConceptScore W3003449791C199343813 @default.
- W3003449791 hasConceptScore W3003449791C2776042228 @default.
- W3003449791 hasConceptScore W3003449791C2776954882 @default.
- W3003449791 hasConceptScore W3003449791C2777419714 @default.
- W3003449791 hasConceptScore W3003449791C2779820397 @default.
- W3003449791 hasConceptScore W3003449791C2780261241 @default.
- W3003449791 hasConceptScore W3003449791C2780352487 @default.
- W3003449791 hasConceptScore W3003449791C2780667556 @default.
- W3003449791 hasConceptScore W3003449791C2780955776 @default.
- W3003449791 hasConceptScore W3003449791C42219234 @default.
- W3003449791 hasConceptScore W3003449791C71924100 @default.
- W3003449791 hasIssue "3" @default.
- W3003449791 hasLocation W30034497911 @default.
- W3003449791 hasLocation W30034497912 @default.
- W3003449791 hasLocation W30034497913 @default.
- W3003449791 hasOpenAccess W3003449791 @default.
- W3003449791 hasPrimaryLocation W30034497911 @default.
- W3003449791 hasRelatedWork W1982256946 @default.
- W3003449791 hasRelatedWork W2037936952 @default.
- W3003449791 hasRelatedWork W2047417898 @default.
- W3003449791 hasRelatedWork W2117367996 @default.