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- W3003614416 endingPage "127003" @default.
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- W3003614416 abstract "A library of 26 novel carboxamides deriving from natural fislatifolic acid has been prepared. The synthetic strategy involved a bio-inspired Diels-Alder cycloaddition, followed by functionalisations of the carbonyl moiety. All the compounds were evaluated on Bcl-xL, Mcl-1 and Bcl-2 proteins. In this series of cyclohexenyl chalcone analogues, six compounds behaved as dual Bcl-xL/Mcl-1 inhibitors in micromolar range and one exhibited sub-micromolar affinities toward Mcl-1 and Bcl-2. The most potent compounds evaluated on A549 and MCF7 cancer cell lines showed moderate cytotoxicities." @default.
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- W3003614416 date "2020-04-01" @default.
- W3003614416 modified "2023-09-25" @default.
- W3003614416 title "Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2" @default.
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- W3003614416 doi "https://doi.org/10.1016/j.bmcl.2020.127003" @default.
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