Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003641515> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3003641515 endingPage "1" @default.
- W3003641515 startingPage "1" @default.
- W3003641515 abstract "An analytical procedure by the inductively coupled plasma mass spectrometry (ICP-MS) is provided to quantitate the remaining phosphorus amount on the surface of the manufacturing equipment for the oligonucleotide active pharmaceutical ingredient (API). In this analytical procedure, the sample solutions obtained from the rinse sampling and direct surface sampling methods are directly injected into the ICP-MS equipment without the inspissation of the extraction liquid. The limit of quantitation for phosphorous was 0.02 µg/mL. Quantitation of phosphorous was achieved over a linear range of 0.02 to 0.8 µg/mL. Analytical validation was carried out to prove that this analytical procedure is appropriate and effective to monitor the cleanliness of the manufacturing equipment after the oligonucleotide API manufacturing and the following cleaning of the equipment. Calibration curve originally passed through the origin with correlation coefficient of 0.999. The precision through the rinse sampling method was within ±10%. The satisfactory accuracy for the rinse sampling method was proven from the assessment of linearity and precision. The precision and accuracy of the analytical procedure were both within ±10% for the direct surface sampling method. The described analytical procedure by ICP-MS following the two types of the sampling procedures can easily be applied to the routine analysis for the verification of the cleanliness of the manufacturing equipment for oligonucleotide API." @default.
- W3003641515 created "2020-02-07" @default.
- W3003641515 creator A5044284847 @default.
- W3003641515 creator A5046946319 @default.
- W3003641515 creator A5049170963 @default.
- W3003641515 date "2020-01-01" @default.
- W3003641515 modified "2023-09-25" @default.
- W3003641515 title "An Analytical Procedure by the Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for the Quantitation of Total Phosphorus Content on the Surface of the Manufacturing Equipment for Oligonucleotides" @default.
- W3003641515 doi "https://doi.org/10.11648/j.sjac.20200801.11" @default.
- W3003641515 hasPublicationYear "2020" @default.
- W3003641515 type Work @default.
- W3003641515 sameAs 3003641515 @default.
- W3003641515 citedByCount "0" @default.
- W3003641515 crossrefType "journal-article" @default.
- W3003641515 hasAuthorship W3003641515A5044284847 @default.
- W3003641515 hasAuthorship W3003641515A5046946319 @default.
- W3003641515 hasAuthorship W3003641515A5049170963 @default.
- W3003641515 hasBestOaLocation W30036415151 @default.
- W3003641515 hasConcept C105795698 @default.
- W3003641515 hasConcept C106131492 @default.
- W3003641515 hasConcept C113196181 @default.
- W3003641515 hasConcept C119128265 @default.
- W3003641515 hasConcept C121332964 @default.
- W3003641515 hasConcept C127413603 @default.
- W3003641515 hasConcept C140779682 @default.
- W3003641515 hasConcept C162356407 @default.
- W3003641515 hasConcept C165697059 @default.
- W3003641515 hasConcept C165838908 @default.
- W3003641515 hasConcept C185592680 @default.
- W3003641515 hasConcept C21880701 @default.
- W3003641515 hasConcept C23531484 @default.
- W3003641515 hasConcept C2780092901 @default.
- W3003641515 hasConcept C31972630 @default.
- W3003641515 hasConcept C33923547 @default.
- W3003641515 hasConcept C41008148 @default.
- W3003641515 hasConcept C43617362 @default.
- W3003641515 hasConcept C62520636 @default.
- W3003641515 hasConcept C82706917 @default.
- W3003641515 hasConcept C95974651 @default.
- W3003641515 hasConceptScore W3003641515C105795698 @default.
- W3003641515 hasConceptScore W3003641515C106131492 @default.
- W3003641515 hasConceptScore W3003641515C113196181 @default.
- W3003641515 hasConceptScore W3003641515C119128265 @default.
- W3003641515 hasConceptScore W3003641515C121332964 @default.
- W3003641515 hasConceptScore W3003641515C127413603 @default.
- W3003641515 hasConceptScore W3003641515C140779682 @default.
- W3003641515 hasConceptScore W3003641515C162356407 @default.
- W3003641515 hasConceptScore W3003641515C165697059 @default.
- W3003641515 hasConceptScore W3003641515C165838908 @default.
- W3003641515 hasConceptScore W3003641515C185592680 @default.
- W3003641515 hasConceptScore W3003641515C21880701 @default.
- W3003641515 hasConceptScore W3003641515C23531484 @default.
- W3003641515 hasConceptScore W3003641515C2780092901 @default.
- W3003641515 hasConceptScore W3003641515C31972630 @default.
- W3003641515 hasConceptScore W3003641515C33923547 @default.
- W3003641515 hasConceptScore W3003641515C41008148 @default.
- W3003641515 hasConceptScore W3003641515C43617362 @default.
- W3003641515 hasConceptScore W3003641515C62520636 @default.
- W3003641515 hasConceptScore W3003641515C82706917 @default.
- W3003641515 hasConceptScore W3003641515C95974651 @default.
- W3003641515 hasIssue "1" @default.
- W3003641515 hasLocation W30036415151 @default.
- W3003641515 hasOpenAccess W3003641515 @default.
- W3003641515 hasPrimaryLocation W30036415151 @default.
- W3003641515 hasRelatedWork W1972707305 @default.
- W3003641515 hasRelatedWork W2019901887 @default.
- W3003641515 hasRelatedWork W2043606423 @default.
- W3003641515 hasRelatedWork W2090937207 @default.
- W3003641515 hasRelatedWork W2121189990 @default.
- W3003641515 hasRelatedWork W2356209107 @default.
- W3003641515 hasRelatedWork W2368840510 @default.
- W3003641515 hasRelatedWork W2386694593 @default.
- W3003641515 hasRelatedWork W2387344420 @default.
- W3003641515 hasRelatedWork W4427527 @default.
- W3003641515 hasVolume "8" @default.
- W3003641515 isParatext "false" @default.
- W3003641515 isRetracted "false" @default.
- W3003641515 magId "3003641515" @default.
- W3003641515 workType "article" @default.