FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003641638> ?p ?o ?g. }

• W3003641638 endingPage "589" @default.
• W3003641638 startingPage "585" @default.
• W3003641638 abstract "Abstract Objective Thromboelastography (TEG) is a point‐of‐care device used to evaluate whole blood coagulation function. The TEG is unique as a test of coagulation function in that it measures the interaction of all components of clot formation, which is different than traditional laboratory‐based tests that measure isolated components of coagulation. Little is known about fetal coagulation physiology. We sought to evaluate the impact of severe fetal anemia and intrauterine transfusion (IUT) on fetal coagulation physiology by use of the TEG and to compare fetal TEG values to those of healthy neonates and adults. Method One milliliter of fetal blood was collected immediately before (pre) and after (post) IUT of packed red blood cells (PRBCs). Sampling and transfusion were performed for fetal anemia due to hemolytic disease of the fetus and newborn. Samples were run in duplicate. For descriptive summary, duplicate pre‐IUT and post‐IUT values were averaged. Values for R (initiation of clot in minutes), K (clot firmness in minutes), angle (kinetics of clot development in degrees), and MA (maximum strength in mm) were obtained for each sample and presented using mean ± SE. Pre‐IUT values for R , K , angle, and MA were compared with post‐IUT values using linear mixed‐effect model to account for clustering due to repeated observation from the same fetus. Pre‐IUT values are compared with normal healthy term neonates and healthy adults using Wald test. The study was approved by the University of Pittsburgh Institutional Review Board (PRO14050051). Results Four fetuses underwent nine IUTs rendering 17 pre‐IUT and 17 post‐IUT specimens. The mean gestational age at IUT was 31 weeks 2 days (25 weeks 4 days to 35 weeks 2 days). The mean IUT volume transfused was 69 mL (30‐170 mL). The mean estimated percent intravascular volume transfused was 33.4% (19%‐52%). Of the four variables analyzed, only R showed a significant difference, with the initiation of clot formation being modestly delayed after transfusion by an estimated 2.87 minutes (95% CI, 0.82‐4.92, P = .0480). Pre‐IUT values were compared with 100 normal term neonates and 118 healthy adults. Compared with pre‐IUT, only R was affected (shorter) compared with term neonates (mean ± SE = 5.46 ± 0.16 minute, P < .001) and healthy adults (mean ± SE = 6.8 ± 0.13 minute, P < .001). Conclusion Other than a modest prolongation of clot formation time, IUT of PRBCs of up to 52% of the estimated intravascular volume did not affect fetal coagulation function by TEG. Other than a shorter clot formation time ( R ), there is no difference in TEG values between anemic preterm fetuses and healthy term neonates and healthy adults. Beyond generalizable knowledge, this information could be exploited for future fetal intervention techniques" @default.
• W3003641638 created "2020-02-07" @default.
• W3003641638 creator A5014917429 @default.
• W3003641638 creator A5036761553 @default.
• W3003641638 creator A5071799465 @default.
• W3003641638 date "2020-02-23" @default.
• W3003641638 modified "2023-09-27" @default.
• W3003641638 title "Impact of intrauterine transfusion on fetal coagulation physiology by thromboelastography" @default.
• W3003641638 cites W1130343390 @default.
• W3003641638 cites W2029841858 @default.
• W3003641638 cites W2034849512 @default.
• W3003641638 cites W2061259945 @default.
• W3003641638 cites W2098624466 @default.
• W3003641638 cites W2231004089 @default.
• W3003641638 cites W2594105398 @default.
• W3003641638 cites W2729783391 @default.
• W3003641638 cites W2897790531 @default.
• W3003641638 doi "https://doi.org/10.1002/pd.5651" @default.
• W3003641638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31994748" @default.
• W3003641638 hasPublicationYear "2020" @default.
• W3003641638 type Work @default.
• W3003641638 sameAs 3003641638 @default.
• W3003641638 citedByCount "0" @default.
• W3003641638 crossrefType "journal-article" @default.
• W3003641638 hasAuthorship W3003641638A5014917429 @default.
• W3003641638 hasAuthorship W3003641638A5036761553 @default.
• W3003641638 hasAuthorship W3003641638A5071799465 @default.
• W3003641638 hasConcept C126322002 @default.
• W3003641638 hasConcept C131872663 @default.
• W3003641638 hasConcept C141071460 @default.
• W3003641638 hasConcept C16124881 @default.
• W3003641638 hasConcept C172680121 @default.
• W3003641638 hasConcept C2777664302 @default.
• W3003641638 hasConcept C2778376644 @default.
• W3003641638 hasConcept C2778382381 @default.
• W3003641638 hasConcept C2779234561 @default.
• W3003641638 hasConcept C2988731192 @default.
• W3003641638 hasConcept C42219234 @default.
• W3003641638 hasConcept C54355233 @default.
• W3003641638 hasConcept C71924100 @default.
• W3003641638 hasConcept C86803240 @default.
• W3003641638 hasConceptScore W3003641638C126322002 @default.
• W3003641638 hasConceptScore W3003641638C131872663 @default.
• W3003641638 hasConceptScore W3003641638C141071460 @default.
• W3003641638 hasConceptScore W3003641638C16124881 @default.
• W3003641638 hasConceptScore W3003641638C172680121 @default.
• W3003641638 hasConceptScore W3003641638C2777664302 @default.
• W3003641638 hasConceptScore W3003641638C2778376644 @default.
• W3003641638 hasConceptScore W3003641638C2778382381 @default.
• W3003641638 hasConceptScore W3003641638C2779234561 @default.
• W3003641638 hasConceptScore W3003641638C2988731192 @default.
• W3003641638 hasConceptScore W3003641638C42219234 @default.
• W3003641638 hasConceptScore W3003641638C54355233 @default.
• W3003641638 hasConceptScore W3003641638C71924100 @default.
• W3003641638 hasConceptScore W3003641638C86803240 @default.
• W3003641638 hasIssue "5" @default.
• W3003641638 hasLocation W30036416381 @default.
• W3003641638 hasOpenAccess W3003641638 @default.
• W3003641638 hasPrimaryLocation W30036416381 @default.
• W3003641638 hasRelatedWork W2012108286 @default.
• W3003641638 hasRelatedWork W2088023878 @default.
• W3003641638 hasRelatedWork W2093251526 @default.
• W3003641638 hasRelatedWork W2522999477 @default.
• W3003641638 hasRelatedWork W2548299699 @default.
• W3003641638 hasRelatedWork W2801463464 @default.
• W3003641638 hasRelatedWork W3006982356 @default.
• W3003641638 hasRelatedWork W3029048307 @default.
• W3003641638 hasRelatedWork W4232056391 @default.
• W3003641638 hasRelatedWork W4253422254 @default.
• W3003641638 hasVolume "40" @default.
• W3003641638 isParatext "false" @default.
• W3003641638 isRetracted "false" @default.
• W3003641638 magId "3003641638" @default.
• W3003641638 workType "article" @default.