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- W3003642257 abstract "Solventogenic clostridia are anaerobic bacteria that can produce butanol, ethanol, and acetone, which can be used as biofuels or building block chemicals. Here, we show that AdhR, a σ 54 -dependent transcriptional activator, senses the intracellular redox status and controls alcohol synthesis in Clostridium beijerinckii . AdhR provides a new example of a GAF domain coordinating a mononuclear non-heme iron to sense and transduce the redox signal. Our study reveals a previously unrecognized functional role of σ 54 in control of cellular redox balance and provides new insights into redox signaling and regulation in clostridia. Our results reveal AdhR as a novel engineering target for improving solvent production by C. beijerinckii and other solventogenic clostridia." @default.
- W3003642257 created "2020-02-07" @default.
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- W3003642257 date "2020-03-18" @default.
- W3003642257 modified "2023-10-15" @default.
- W3003642257 title "Ferrous-Iron-Activated Transcriptional Factor AdhR Regulates Redox Homeostasis in <i>Clostridium beijerinckii</i>" @default.
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- W3003642257 doi "https://doi.org/10.1128/aem.02782-19" @default.
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