FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003642268> ?p ?o ?g. }

• W3003642268 endingPage "431" @default.
• W3003642268 startingPage "422" @default.
• W3003642268 abstract "Cholesteryl ester transfer protein (CETP) exists as full-length (FL) and exon 9 (E9)-deleted isoforms. The function of E9-deleted CETP is poorly understood. Here, we investigated the role of E9-deleted CETP in regulating the secretion of FL-CETP by cells and explored its possible role in intracellular lipid metabolism. CETP overexpression in cells that naturally express CETP confirmed that E9-deleted CETP is not secreted, and showed that cellular FL- and E9-deleted CETP form an isolatable complex. Coexpression of CETP isoforms lowered cellular levels of both proteins and impaired FL-CETP secretion. These effects were due to reduced synthesis of both isoforms; however, the predominate consequence of FL- and E9-deleted CETP coexpression is impaired FL-CETP synthesis. We reported previously that reducing both CETP isoforms or overexpressing FL-CETP impairs cellular triglyceride (TG) storage. To investigate this further, E9-deleted CETP was expressed in SW872 cells that naturally synthesize CETP and in mouse 3T3-L1 cells that do not. E9-deleted CETP overexpression stimulated SW872 triglyceride synthesis and increased stored TG 2-fold. Expression of E9-deleted CETP in mouse 3T3-L1 cells produced a similar lipid phenotype. In vitro, FL-CETP promotes the transfer of TG from ER-enriched membranes to lipid droplets. E9-deleted CETP also promoted this transfer, although less effectively, and it inhibited the transfer driven by FL-CETP. We conclude that FL- and E9-deleted CETP isoforms interact to mutually decrease their intracellular levels and impair FL-CETP secretion by reducing CETP biosynthesis. E9-deleted CETP, like FL-CETP, alters cellular TG metabolism and storage but in a contrary manner." @default.
• W3003642268 created "2020-02-07" @default.
• W3003642268 creator A5021293751 @default.
• W3003642268 creator A5038914339 @default.
• W3003642268 creator A5055612276 @default.
• W3003642268 date "2020-03-01" @default.
• W3003642268 modified "2023-10-16" @default.
• W3003642268 title "Exon 9-deleted CETP inhibits full length-CETP synthesis and promotes cellular triglyceride storage" @default.
• W3003642268 cites W1491391137 @default.
• W3003642268 cites W1501497997 @default.
• W3003642268 cites W1510710298 @default.
• W3003642268 cites W1519042393 @default.
• W3003642268 cites W1519619661 @default.
• W3003642268 cites W1531097940 @default.
• W3003642268 cites W1554328811 @default.
• W3003642268 cites W1607085392 @default.
• W3003642268 cites W1672901017 @default.
• W3003642268 cites W1966124841 @default.
• W3003642268 cites W1967650076 @default.
• W3003642268 cites W1969260244 @default.
• W3003642268 cites W1974130390 @default.
• W3003642268 cites W1981899962 @default.
• W3003642268 cites W1995696342 @default.
• W3003642268 cites W2000683862 @default.
• W3003642268 cites W2004359169 @default.
• W3003642268 cites W2020108444 @default.
• W3003642268 cites W2026439495 @default.
• W3003642268 cites W2027118463 @default.
• W3003642268 cites W2030164878 @default.
• W3003642268 cites W2039933658 @default.
• W3003642268 cites W2058735916 @default.
• W3003642268 cites W2058805223 @default.
• W3003642268 cites W2060907571 @default.
• W3003642268 cites W2061380831 @default.
• W3003642268 cites W2078932024 @default.
• W3003642268 cites W2083888364 @default.
• W3003642268 cites W2089229681 @default.
• W3003642268 cites W2100689343 @default.
• W3003642268 cites W2102131116 @default.
• W3003642268 cites W2103644580 @default.
• W3003642268 cites W2116476575 @default.
• W3003642268 cites W2123248870 @default.
• W3003642268 cites W2135503869 @default.
• W3003642268 cites W2144872535 @default.
• W3003642268 cites W2148417474 @default.
• W3003642268 cites W2166606079 @default.
• W3003642268 cites W2169758698 @default.
• W3003642268 cites W2287812015 @default.
• W3003642268 cites W2295460934 @default.
• W3003642268 cites W2399613397 @default.
• W3003642268 cites W2412426402 @default.
• W3003642268 cites W2614618572 @default.
• W3003642268 cites W2902674068 @default.
• W3003642268 cites W2946098128 @default.
• W3003642268 cites W2974819168 @default.
• W3003642268 doi "https://doi.org/10.1194/jlr.ra120000583" @default.
• W3003642268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7053842" @default.
• W3003642268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31988147" @default.
• W3003642268 hasPublicationYear "2020" @default.
• W3003642268 type Work @default.
• W3003642268 sameAs 3003642268 @default.
• W3003642268 citedByCount "5" @default.
• W3003642268 countsByYear W30036422682020 @default.
• W3003642268 countsByYear W30036422682021 @default.
• W3003642268 countsByYear W30036422682023 @default.
• W3003642268 crossrefType "journal-article" @default.
• W3003642268 hasAuthorship W3003642268A5021293751 @default.
• W3003642268 hasAuthorship W3003642268A5038914339 @default.
• W3003642268 hasAuthorship W3003642268A5055612276 @default.
• W3003642268 hasBestOaLocation W30036422681 @default.
• W3003642268 hasConcept C104317684 @default.
• W3003642268 hasConcept C185592680 @default.
• W3003642268 hasConcept C2778163477 @default.
• W3003642268 hasConcept C2778913445 @default.
• W3003642268 hasConcept C2780072125 @default.
• W3003642268 hasConcept C45505151 @default.
• W3003642268 hasConcept C49039625 @default.
• W3003642268 hasConcept C53345823 @default.
• W3003642268 hasConcept C55493867 @default.
• W3003642268 hasConcept C79879829 @default.
• W3003642268 hasConcept C86803240 @default.
• W3003642268 hasConcept C95444343 @default.
• W3003642268 hasConceptScore W3003642268C104317684 @default.
• W3003642268 hasConceptScore W3003642268C185592680 @default.
• W3003642268 hasConceptScore W3003642268C2778163477 @default.
• W3003642268 hasConceptScore W3003642268C2778913445 @default.
• W3003642268 hasConceptScore W3003642268C2780072125 @default.
• W3003642268 hasConceptScore W3003642268C45505151 @default.
• W3003642268 hasConceptScore W3003642268C49039625 @default.
• W3003642268 hasConceptScore W3003642268C53345823 @default.
• W3003642268 hasConceptScore W3003642268C55493867 @default.
• W3003642268 hasConceptScore W3003642268C79879829 @default.
• W3003642268 hasConceptScore W3003642268C86803240 @default.
• W3003642268 hasConceptScore W3003642268C95444343 @default.
• W3003642268 hasFunder F4320337338 @default.
• W3003642268 hasIssue "3" @default.
• W3003642268 hasLocation W30036422681 @default.
• W3003642268 hasLocation W30036422682 @default.

• next