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- W3003646060 endingPage "8072" @default.
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- W3003646060 abstract "Thiol-maleimide and thiol-vinylsulfone cross-linked hydrogels are widely used systems in 3D culture models, in spite of presenting uncomfortable reaction kinetics for cell encapsulation: too fast (seconds for thiol-maleimide) or too slow (minutes-hours for thiol-vinylsulfone). Here, we introduce the thiol-methylsulfone reaction as alternative cross-linking chemistry for cell encapsulation, particularized for PEG-hydrogels. The thiol-methylsulfone reaction occurs at high conversion and at intermediate reaction speed (seconds-minutes) under physiological pH range. These properties allow easy mixing of hydrogel precursors and cells to render homogeneous cell-laden gels at comfortable experimental time scales. The resulting hydrogels are cytocompatible and show comparable hydrolytic stability to thiol-vinylsulfone gels. They allow direct bioconjugation of thiol-derivatized ligands and tunable degradation kinetics by cross-linking with degradable peptide sequences. 3D cell culture of two cell types, fibroblasts and human umbilical vein endothelial cells (HUVECs), is demonstrated." @default.
- W3003646060 created "2020-02-07" @default.
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- W3003646060 date "2020-01-30" @default.
- W3003646060 modified "2023-10-16" @default.
- W3003646060 title "Thiol-Methylsulfone-Based Hydrogels for 3D Cell Encapsulation" @default.
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- W3003646060 doi "https://doi.org/10.1021/acsami.0c00709" @default.
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