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- W3003670335 endingPage "153" @default.
- W3003670335 startingPage "131" @default.
- W3003670335 abstract "Asthma and chronic obstructive pulmonary disease (COPD) represent the two most common obstructive lung diseases worldwide, imparting a significant global public health burden. Both are now recognized as umbrella terms capturing heterogeneous collections of disorders, rather than a single disease, and the existence of subset of individuals with asthma–COPD overlap (ACO) further contributes to this complexity. Consequently, it is increasingly recognized that a one-size-fits-all therapeutic approach is insufficient to manage these obstructive lung diseases, and that phenotypic characteristics alone are insufficient to define them. Instead, the field is turning to endotyping, that is, identifying subgroups of similar individuals based on the pathobiological mechanisms underlying their disease, and using this mechanistic information to target therapeutics. There have been a number of notable successes for certain endotypes of asthma in this regard, particularly for Type 2-driven asthma. However, developments for non-Type 2 asthma, COPD and ACO are lagging behind. Omics technologies (i.e., genomics, epigenomics, transcriptomics, proteomics, and metabolomics) represent a compelling new approach for the generation of endotyping and therapeutic biomarkers for the spectrum of these disorders. However, technological and analytical advances, and an improved biological understanding are required before precision medicine initiatives can be translated into common clinical practice for obstructive lung diseases." @default.
- W3003670335 created "2020-02-07" @default.
- W3003670335 creator A5008972550 @default.
- W3003670335 creator A5013008663 @default.
- W3003670335 creator A5045120834 @default.
- W3003670335 date "2020-01-01" @default.
- W3003670335 modified "2023-09-27" @default.
- W3003670335 title "Biomarkers in Obstructive Airway Diseases" @default.
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