FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003682012> ?p ?o ?g. }

• W3003682012 endingPage "146698" @default.
• W3003682012 startingPage "146698" @default.
• W3003682012 abstract "PAX6 encodes a highly conserved transcription factor necessary for normal development of the eyes and central nervous system. Heterozygous loss-of-function mutations in PAX6 cause the disorder aniridia in humans and the Small eye trait in mice. Aniridia is a congenital and progressive disorder known for ocular phenotypes; however, recently, consequences of PAX6 haploinsufficiency in the brains of aniridia patients have been identified. These findings span structural and functional abnormalities, including deficits in cognitive and sensory processing. Furthermore, some of these abnormalities are accelerated as aniridia patients age. Although some functional abnormalities may be explained by structural changes, variability of results remain, and the effects of PAX6 heterozygous loss-of-function mutations on neuroanatomy, particularly with regard to aging, have yet to be resolved. Our study used high-resolution magnetic resonance imaging (MRI) and histology to investigate structural consequences of such mutations in the adult brain of our aniridia mouse model, Small eye Neuherberg allele (Pax6SeyNeu/+), at two adult age groups. Using both MRI and histology enables a direct comparison with human studies, while providing higher resolution for detection of more subtle changes. We show volumetric changes in major brain regions of the the Pax6SeyNeu/+ mouse compared to wild-type including genotype- and age-related olfactory bulb differences, age-related cerebellum differences, and genotype-related eye differences. We also show alterations in thickness of major interhemispheric commissures, particularly those anteriorly located within the brain including the optic chiasm, corpus callosum, and anterior commissure. Together, these genotype and age related changes to brain volumes and structures suggest a global decrease in adult brain structural plasticity in our Pax6SeyNeu/+ mice." @default.
• W3003682012 created "2020-02-07" @default.
• W3003682012 creator A5005773282 @default.
• W3003682012 creator A5051968519 @default.
• W3003682012 creator A5054932050 @default.
• W3003682012 creator A5056511375 @default.
• W3003682012 creator A5069049550 @default.
• W3003682012 creator A5069341417 @default.
• W3003682012 creator A5087803611 @default.
• W3003682012 date "2020-04-01" @default.
• W3003682012 modified "2023-10-18" @default.
• W3003682012 title "Global and age-related neuroanatomical abnormalities in a Pax6-deficient mouse model of aniridia suggests a role for Pax6 in adult structural neuroplasticity" @default.
• W3003682012 cites W1613795242 @default.
• W3003682012 cites W1882974721 @default.
• W3003682012 cites W1933799138 @default.
• W3003682012 cites W1957841482 @default.
• W3003682012 cites W1964784784 @default.
• W3003682012 cites W1967679856 @default.
• W3003682012 cites W1978187692 @default.
• W3003682012 cites W1984891852 @default.
• W3003682012 cites W1985957476 @default.
• W3003682012 cites W1988037565 @default.
• W3003682012 cites W1995417282 @default.
• W3003682012 cites W1997991955 @default.
• W3003682012 cites W2000955502 @default.
• W3003682012 cites W2015615191 @default.
• W3003682012 cites W2015765031 @default.
• W3003682012 cites W2017954097 @default.
• W3003682012 cites W2024914489 @default.
• W3003682012 cites W2031188043 @default.
• W3003682012 cites W2033507564 @default.
• W3003682012 cites W2033690523 @default.
• W3003682012 cites W2035850583 @default.
• W3003682012 cites W2045462596 @default.
• W3003682012 cites W2046060229 @default.
• W3003682012 cites W2049148593 @default.
• W3003682012 cites W2052142315 @default.
• W3003682012 cites W2053729206 @default.
• W3003682012 cites W2055940932 @default.
• W3003682012 cites W2059824340 @default.
• W3003682012 cites W2066463301 @default.
• W3003682012 cites W2067315256 @default.
• W3003682012 cites W2068339715 @default.
• W3003682012 cites W2069270259 @default.
• W3003682012 cites W2077423081 @default.
• W3003682012 cites W2084557287 @default.
• W3003682012 cites W2085016362 @default.
• W3003682012 cites W2085542981 @default.
• W3003682012 cites W2086359697 @default.
• W3003682012 cites W2091858601 @default.
• W3003682012 cites W2096679749 @default.
• W3003682012 cites W2099046541 @default.
• W3003682012 cites W2105460000 @default.
• W3003682012 cites W2111559291 @default.
• W3003682012 cites W2118161962 @default.
• W3003682012 cites W2118746463 @default.
• W3003682012 cites W2119167695 @default.
• W3003682012 cites W2126705032 @default.
• W3003682012 cites W2134413846 @default.
• W3003682012 cites W2139103260 @default.
• W3003682012 cites W2147977861 @default.
• W3003682012 cites W2150129913 @default.
• W3003682012 cites W2150190299 @default.
• W3003682012 cites W2158564610 @default.
• W3003682012 cites W2163008799 @default.
• W3003682012 cites W2170563276 @default.
• W3003682012 cites W2171508208 @default.
• W3003682012 cites W2315139940 @default.
• W3003682012 cites W2328238395 @default.
• W3003682012 cites W2337288008 @default.
• W3003682012 cites W2489268322 @default.
• W3003682012 cites W2595520049 @default.
• W3003682012 cites W2951859448 @default.
• W3003682012 cites W4239431608 @default.
• W3003682012 cites W4323238746 @default.
• W3003682012 doi "https://doi.org/10.1016/j.brainres.2020.146698" @default.
• W3003682012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32014531" @default.
• W3003682012 hasPublicationYear "2020" @default.
• W3003682012 type Work @default.
• W3003682012 sameAs 3003682012 @default.
• W3003682012 citedByCount "5" @default.
• W3003682012 countsByYear W30036820122020 @default.
• W3003682012 countsByYear W30036820122021 @default.
• W3003682012 countsByYear W30036820122022 @default.
• W3003682012 countsByYear W30036820122023 @default.
• W3003682012 crossrefType "journal-article" @default.
• W3003682012 hasAuthorship W3003682012A5005773282 @default.
• W3003682012 hasAuthorship W3003682012A5051968519 @default.
• W3003682012 hasAuthorship W3003682012A5054932050 @default.
• W3003682012 hasAuthorship W3003682012A5056511375 @default.
• W3003682012 hasAuthorship W3003682012A5069049550 @default.
• W3003682012 hasAuthorship W3003682012A5069341417 @default.
• W3003682012 hasAuthorship W3003682012A5087803611 @default.
• W3003682012 hasConcept C104317684 @default.
• W3003682012 hasConcept C127716648 @default.
• W3003682012 hasConcept C169760540 @default.
• W3003682012 hasConcept C2776608714 @default.
• W3003682012 hasConcept C2778085061 @default.

• next