FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003701006> ?p ?o ?g. }

• W3003701006 endingPage "23185" @default.
• W3003701006 startingPage "23179" @default.
• W3003701006 abstract "Deciphering the dynamic changes of core factors at different reprogramming stages plays an important role in elucidating the reprogramming mechanism of induced pluripotent stem cells (iPSCs) and improving their induction efficiency. The use of transcription factors (TFs) in combination with histone modification is vital to understand the multiple regulatory of pioneer factor. However, existing studies are not enough to consider the classification of stage-specific gene clusters from the perspective of multi-omic in the process of cell reprogramming. In this study, three stage-specific gene clusters of reprogramming initiation, maturation and stabilization phase were identified by using differential expression analysis. Considering the effects of regional binding preference, we further constructed a quantitative model on different genome regions (promoter, enhancer and enhancer subdivision region) by integrating the DNA binding profiles of Oct4 and three histone modifications (HMs). For promoter and enhancer regions, the receiver operating characteristic curve (Roc curve) of support vector machine (SVM) model was above 0.75 and predictive with the accuracy (Acc) about 66~69%. But on enhancer subdivision region, the convolutional neural network (CNN) model we constructed showed more faithful predictive performance than the model on promoter and enhancer, which Roc curve area can reach 0.87. Taken together, our studies quantitatively reveal the cooperative effects of TFs and HMs on reprogramming stage-specific gene clusters, hoping to provide new sights in mining the key regulators of reprogramming." @default.
• W3003701006 created "2020-02-07" @default.
• W3003701006 creator A5001300435 @default.
• W3003701006 creator A5062770273 @default.
• W3003701006 creator A5085057160 @default.
• W3003701006 creator A5090788114 @default.
• W3003701006 date "2020-01-01" @default.
• W3003701006 modified "2023-10-16" @default.
• W3003701006 title "Mining Key Regulators of Cell Reprogramming and Prediction Research Based on Deep Learning Neural Networks" @default.
• W3003701006 cites W1533908931 @default.
• W3003701006 cites W1585888846 @default.
• W3003701006 cites W1602568023 @default.
• W3003701006 cites W1978173381 @default.
• W3003701006 cites W1985147449 @default.
• W3003701006 cites W2010672807 @default.
• W3003701006 cites W2026029065 @default.
• W3003701006 cites W2076063813 @default.
• W3003701006 cites W2095417588 @default.
• W3003701006 cites W2112796928 @default.
• W3003701006 cites W2124985265 @default.
• W3003701006 cites W2125987139 @default.
• W3003701006 cites W2138977668 @default.
• W3003701006 cites W2144091055 @default.
• W3003701006 cites W2148679920 @default.
• W3003701006 cites W2170830174 @default.
• W3003701006 cites W2208578958 @default.
• W3003701006 cites W2259708197 @default.
• W3003701006 cites W2479945688 @default.
• W3003701006 cites W2513786151 @default.
• W3003701006 cites W2580390259 @default.
• W3003701006 cites W2737942054 @default.
• W3003701006 cites W2810876096 @default.
• W3003701006 cites W2892079508 @default.
• W3003701006 cites W2895511614 @default.
• W3003701006 cites W2905691307 @default.
• W3003701006 cites W2921746589 @default.
• W3003701006 cites W2937145808 @default.
• W3003701006 cites W2942797953 @default.
• W3003701006 cites W2943386850 @default.
• W3003701006 cites W2946035471 @default.
• W3003701006 cites W2948476060 @default.
• W3003701006 cites W2949453554 @default.
• W3003701006 cites W2964443466 @default.
• W3003701006 cites W2972657204 @default.
• W3003701006 cites W94414152 @default.
• W3003701006 doi "https://doi.org/10.1109/access.2020.2970442" @default.
• W3003701006 hasPublicationYear "2020" @default.
• W3003701006 type Work @default.
• W3003701006 sameAs 3003701006 @default.
• W3003701006 citedByCount "4" @default.
• W3003701006 countsByYear W30037010062020 @default.
• W3003701006 countsByYear W30037010062022 @default.
• W3003701006 countsByYear W30037010062023 @default.
• W3003701006 crossrefType "journal-article" @default.
• W3003701006 hasAuthorship W3003701006A5001300435 @default.
• W3003701006 hasAuthorship W3003701006A5062770273 @default.
• W3003701006 hasAuthorship W3003701006A5085057160 @default.
• W3003701006 hasAuthorship W3003701006A5090788114 @default.
• W3003701006 hasBestOaLocation W30037010061 @default.
• W3003701006 hasConcept C104317684 @default.
• W3003701006 hasConcept C107459253 @default.
• W3003701006 hasConcept C111936080 @default.
• W3003701006 hasConcept C119857082 @default.
• W3003701006 hasConcept C145103041 @default.
• W3003701006 hasConcept C150194340 @default.
• W3003701006 hasConcept C41008148 @default.
• W3003701006 hasConcept C54355233 @default.
• W3003701006 hasConcept C67339327 @default.
• W3003701006 hasConcept C70721500 @default.
• W3003701006 hasConcept C77255625 @default.
• W3003701006 hasConcept C81363708 @default.
• W3003701006 hasConcept C86339819 @default.
• W3003701006 hasConcept C86803240 @default.
• W3003701006 hasConceptScore W3003701006C104317684 @default.
• W3003701006 hasConceptScore W3003701006C107459253 @default.
• W3003701006 hasConceptScore W3003701006C111936080 @default.
• W3003701006 hasConceptScore W3003701006C119857082 @default.
• W3003701006 hasConceptScore W3003701006C145103041 @default.
• W3003701006 hasConceptScore W3003701006C150194340 @default.
• W3003701006 hasConceptScore W3003701006C41008148 @default.
• W3003701006 hasConceptScore W3003701006C54355233 @default.
• W3003701006 hasConceptScore W3003701006C67339327 @default.
• W3003701006 hasConceptScore W3003701006C70721500 @default.
• W3003701006 hasConceptScore W3003701006C77255625 @default.
• W3003701006 hasConceptScore W3003701006C81363708 @default.
• W3003701006 hasConceptScore W3003701006C86339819 @default.
• W3003701006 hasConceptScore W3003701006C86803240 @default.
• W3003701006 hasFunder F4320321001 @default.
• W3003701006 hasLocation W30037010061 @default.
• W3003701006 hasLocation W30037010062 @default.
• W3003701006 hasOpenAccess W3003701006 @default.
• W3003701006 hasPrimaryLocation W30037010061 @default.
• W3003701006 hasRelatedWork W1888433033 @default.
• W3003701006 hasRelatedWork W2392750004 @default.
• W3003701006 hasRelatedWork W2415743749 @default.
• W3003701006 hasRelatedWork W2418603484 @default.
• W3003701006 hasRelatedWork W2479215566 @default.
• W3003701006 hasRelatedWork W2744405843 @default.

• next