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• W3003721121 abstract "Toxoplasma gondii is a foodborne parasite that infects virtually all warm-blooded animals and can cause severe disease in individuals with compromised or weakened immune systems. During dissemination in its infected hosts, T. gondii breaches endothelial barriers to enter tissues and establish the chronic infections underlying the most severe manifestations of toxoplasmosis. The research presented here examines how T. gondii infection of primary human endothelial cells induces changes in cell morphology, barrier function, gene expression, and mechanotransduction signaling under static conditions and under the physiological conditions of shear stress found in the bloodstream. Understanding the molecular interactions occurring at the interface between endothelial cells and T. gondii may provide insights into processes linked to parasite dissemination and pathogenesis." @default.
• W3003721121 created "2020-02-07" @default.
• W3003721121 creator A5018821990 @default.
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• W3003721121 date "2020-02-26" @default.
• W3003721121 modified "2023-10-14" @default.
• W3003721121 title "Toxoplasma gondii Dysregulates Barrier Function and Mechanotransduction Signaling in Human Endothelial Cells" @default.
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• W3003721121 doi "https://doi.org/10.1128/msphere.00550-19" @default.
• W3003721121 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6992369" @default.
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