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• W3003753234 abstract "Although antidepressants can relieve the symptoms of depression in patients with type-2 diabetes mellitus, the effect of vitamin D supplementation as an antidepressant remains unclear. The present study aimed to investigate the impact of intramuscular vitamin D supplement injections on depression and anthropometric indices in patients with type 2 diabetes who had vitamin D deficiency. In this randomized controlled clinical trial, 50 patients with type 2 diabetes mellitus who had vitamin D deficiency were randomly divided into two groups of 25 participants. The experimental group received 200,000 IU of vitamin D injection at week 0 and week 4 of the study. Anthropometric indices, serum 25-hydroxyvitamin D [25(OH)D] concentrations and Beck depression test were evaluated at the beginning and after 8 weeks. There were no significant differences in the baseline measures of 25(OH)D concentrations between the experimental and the non-experimental groups (P = 0.78). No significant correlation was observed between the depression score and serum 25(OH)D concentrations (r = -0.008, P = 0.95). After two months, serum 25(OH)D concentrations significantly increased in the experimental group compared with the non-experimental group (p < 0.001). The mean measures of weight, fat level, waist to hip circumference ratio and the mean depression score were not significant in the two groups after the intervention. The intramuscular vitamin D supplement injections increased serum 25(OH)D concentrations in patients with type 2 diabetes mellitus who had vitamin D deficiency, while it had no significant effect on the depression status. (http://www.irct.ir:IRCT20171003036539N2)." @default.
• W3003753234 created "2020-02-07" @default.
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• W3003753234 date "2020-03-01" @default.
• W3003753234 modified "2023-10-18" @default.
• W3003753234 title "The effect of high dose of intramuscular vitamin D supplement injections on depression in patients with type 2 diabetes and vitamin D deficiency: A randomized controlled clinical trial" @default.
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• W3003753234 doi "https://doi.org/10.1016/j.obmed.2020.100192" @default.
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