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• W3003787546 abstract "The HIV latent reservoir in resting memory CD4+ T cells precludes cure. Therapeutics to reactivate and eliminate this reservoir are in clinical trials in adults, but not yet in pediatric populations. We determined, ex vivo, the inducibility of the latent reservoir in perinatal infection as compared with adult infections using the Tat/rev induced limiting dilution assay (TILDA), in which a single round (12 hours) of CD4+ T cell stimulation with PMA/ionomycin maximally activates T cells and leads to proviral expression with multiply spliced HIV RNA production. Markers of immune activation and exhaustion were measured to assess interactions with inducibility. Although rates of T cell activation with PMA/ionomycin were similar, the latent reservoir in perinatal infection was slower to reactivate and of lower magnitude compared with adult infection, independent of proviral load. An enhanced TILDA with the addition of phytohemagglutin and a duration of 18 hours augmented proviral expression in perinatal but not adult infection. The baseline HLA-DR+CD4+ T cell level was significantly lower in perinatal compared with adult infections, but not correlated with induced reservoir size. These data support the hypothesis that there are differences in kinetics of latency reversal and baseline immune activation in perinatal compared with adult infections, with implications for latency reversal strategies toward reservoir clearance and remission." @default.
• W3003787546 created "2020-02-07" @default.
• W3003787546 creator A5007613574 @default.
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• W3003787546 date "2020-02-27" @default.
• W3003787546 modified "2023-09-27" @default.
• W3003787546 title "Differences in inducibility of the latent HIV reservoir in perinatal and adult infection" @default.
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• W3003787546 doi "https://doi.org/10.1172/jci.insight.134105" @default.
• W3003787546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7101150" @default.
• W3003787546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31999647" @default.
• W3003787546 hasPublicationYear "2020" @default.
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