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• W3003826472 abstract "Mechanical ventilation with hyperoxia is the major supportive measure to treat patients with acute lung injury and acute respiratory distress syndrome (ARDS). However, prolonged exposure to hyperoxia can induce oxidative inflammatory lung injury. Previously, we have shown that high levels of airway high-mobility group box 1 protein (HMGB1) mediate hyperoxia-induced acute lung injury (HALI). Using both ascorbic acid (AA, also known as vitamin C) and sulforaphane (SFN), an inducer of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), we tested the hypothesis that dietary antioxidants can mitigate HALI by ameliorating HMGB1-compromised macrophage function in phagocytosis by attenuating hyperoxia-induced extracellular HMGB1 accumulation. Our results indicated that SFN, which has been shown to attenute HALI in mice exposed to hyperoxia, dose-dependently restored hyperoxia-compromised macrophage function in phagocytosis (75.9 ± 3.5% in 0.33 µM SFN versus 50.7 ± 1.8% in dimethyl sulfoxide (DMSO) control, p < 0.05) by reducing oxidative stress and HMGB1 release from cultured macrophages (47.7 ± 14.7% in 0.33 µM SFN versus 93.1 ± 14.6% in DMSO control, p < 0.05). Previously, we have shown that AA enhances hyperoxic macrophage functions by reducing hyperoxia-induced HMGB1 release. Using a mouse model of HALI, we determined the effects of AA on hyperoxia-induced inflammatory lung injury. The i.p. administration of 50 mg/kg of AA to mice exposed to 72 h of ≥98% O2 significantly decreased hyperoxia-induced oxidative and nitrosative stress in mouse lungs. There was a significant decrease in the levels of airway HMGB1 (43.3 ± 12.2% in 50 mg/kg AA versus 96.7 ± 9.39% in hyperoxic control, p < 0.05), leukocyte infiltration (60.39 ± 4.137% leukocytes numbers in 50 mg/kg AA versus 100 ± 5.82% in hyperoxic control, p < 0.05) and improved lung integrity in mice treated with AA. Our study is the first to report that the dietary antioxidants, ascorbic acid and sulforaphane, ameliorate HALI and attenuate hyperoxia-induced macrophage dysfunction through an HMGB1-mediated pathway. Thus, dietary antioxidants could be used as potential treatments for oxidative-stress-induced acute inflammatory lung injury in patients receiving mechanical ventilation." @default.
• W3003826472 created "2020-02-07" @default.
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• W3003826472 date "2020-02-01" @default.
• W3003826472 modified "2023-10-03" @default.
• W3003826472 title "Dietary Antioxidants Significantly Attenuate Hyperoxia-Induced Acute Inflammatory Lung Injury by Enhancing Macrophage Function via Reducing the Accumulation of Airway HMGB1" @default.
• W3003826472 cites W1493525820 @default.
• W3003826472 cites W1550989404 @default.
• W3003826472 cites W1573103899 @default.
• W3003826472 cites W1592576901 @default.
• W3003826472 cites W1948225098 @default.
• W3003826472 cites W1977812519 @default.
• W3003826472 cites W1983590674 @default.
• W3003826472 cites W1990223276 @default.
• W3003826472 cites W1990709215 @default.
• W3003826472 cites W1994190235 @default.
• W3003826472 cites W1995593745 @default.
• W3003826472 cites W2000017694 @default.
• W3003826472 cites W2014607047 @default.
• W3003826472 cites W2030325789 @default.
• W3003826472 cites W2032865299 @default.
• W3003826472 cites W2033189574 @default.
• W3003826472 cites W2033287913 @default.
• W3003826472 cites W2035676834 @default.
• W3003826472 cites W2043547789 @default.
• W3003826472 cites W2049474209 @default.
• W3003826472 cites W2056241473 @default.
• W3003826472 cites W2073330771 @default.
• W3003826472 cites W2090300161 @default.
• W3003826472 cites W2092643175 @default.
• W3003826472 cites W2095537212 @default.
• W3003826472 cites W2096771598 @default.
• W3003826472 cites W2104595095 @default.
• W3003826472 cites W2105095232 @default.
• W3003826472 cites W2118056311 @default.
• W3003826472 cites W2118989469 @default.
• W3003826472 cites W2136160240 @default.
• W3003826472 cites W2142291450 @default.
• W3003826472 cites W2146682756 @default.
• W3003826472 cites W2146807706 @default.
• W3003826472 cites W2147061446 @default.
• W3003826472 cites W2147230285 @default.
• W3003826472 cites W2154666961 @default.
• W3003826472 cites W2156057127 @default.
• W3003826472 cites W2160292216 @default.
• W3003826472 cites W2161568523 @default.
• W3003826472 cites W2164714222 @default.
• W3003826472 cites W2170022542 @default.
• W3003826472 cites W2195825853 @default.
• W3003826472 cites W2202703189 @default.
• W3003826472 cites W2290466312 @default.
• W3003826472 cites W2292730121 @default.
• W3003826472 cites W2328643786 @default.
• W3003826472 cites W2343643256 @default.
• W3003826472 cites W2514636631 @default.
• W3003826472 cites W2560240742 @default.
• W3003826472 cites W2597877147 @default.
• W3003826472 cites W2624371671 @default.
• W3003826472 cites W2750054522 @default.
• W3003826472 cites W2752084332 @default.
• W3003826472 cites W2766820812 @default.
• W3003826472 cites W2780408352 @default.
• W3003826472 cites W2790266513 @default.
• W3003826472 cites W2793394069 @default.
• W3003826472 cites W2793513555 @default.
• W3003826472 cites W2794139372 @default.
• W3003826472 cites W2796338644 @default.
• W3003826472 cites W2809261456 @default.
• W3003826472 cites W2889778156 @default.
• W3003826472 cites W2905546571 @default.
• W3003826472 cites W2915800400 @default.
• W3003826472 cites W2928134763 @default.
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• W3003826472 doi "https://doi.org/10.3390/ijms21030977" @default.
• W3003826472 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7037000" @default.
• W3003826472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32024151" @default.
• W3003826472 hasPublicationYear "2020" @default.
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