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- W3003838412 abstract "Fat MetabolismAn exploration of how lipolysis is coupled to mitochondrial changes that increase oxidative capacity may reveal how a Mediterranean diet is beneficial. Najt et al. found that monounsaturated fatty acids (MUFAs) released by lipolysis bound to the protein perilipin 5, which carried them to the nucleus. MUFAs also bound to the deacetylase sirtuin 1 (SIRT1), which is implicated in the health span–improving effects of caloric restriction. MUFA binding increased SIRT1 activity toward certain substrates. Foods like nuts, avocados, and olive oil all provide MUFAs in the diet, and these effects could in part underlie their beneficial properties.Mol. Cell 10.1016/j.molcel.2019.12.003 (2020)." @default.
- W3003838412 created "2020-02-07" @default.
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- W3003838412 date "2020-01-30" @default.
- W3003838412 modified "2023-09-25" @default.
- W3003838412 title "Signals from lipid hydrolysis" @default.
- W3003838412 doi "https://doi.org/10.1126/science.367.6477.523-c" @default.
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