FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003914908> ?p ?o ?g. }

• W3003914908 endingPage "696" @default.
• W3003914908 startingPage "691" @default.
• W3003914908 abstract "Background: Faster insulin aspart is a novel formulation of insulin aspart aiming to accelerate its subcutaneous absorption. The aim of this study was to compare pharmacokinetics of faster insulin aspart versus standard insulin aspart in adults with type 2 diabetes during closed-loop insulin delivery. Methods: We assessed the pharmacokinetics of faster and standard insulin aspart from data obtained in a randomized double-blind crossover study evaluating fully closed-loop insulin delivery in adults with type 2 diabetes (n = 13, age 59 ± 10 years, BMI 34.5 ± 9.1 kg/m2, HbA1c 7.7% ± 1.2% [60 ± 13 mmol/mol]). Blood samples were collected every 15-30 min for 10 h to determine plasma insulin aspart concentration using liquid chromatography mass spectrometry. Time to peak plasma concentration (Tmax) was calculated using a two-compartment model. Results:Tmax was 68.7 ± 21.6 min for faster aspart and 89.7 ± 31.8 min for aspart (mean paired difference faster aspart minus aspart -15.5 min, 95% CI [-31.6 to 0.6 min], P = 0.06). Metabolic clearance rate did not differ between the two insulins (P = 0.61). Insulin amount delivered during closed-loop with faster aspart positively correlated with Tmax (rS = 0.73, P = 0.01), whereas no statistically significant correlation was found with body mass index (BMI), weight or HbA1C (all P > 0.18). Conclusion: In conclusion, Tmax tended to be shorter for faster aspart versus aspart during fully automated closed-loop insulin delivery and positively correlated with the amount of insulin delivered." @default.
• W3003914908 created "2020-02-07" @default.
• W3003914908 creator A5012170772 @default.
• W3003914908 creator A5017090852 @default.
• W3003914908 creator A5018676268 @default.
• W3003914908 creator A5018957018 @default.
• W3003914908 creator A5028753329 @default.
• W3003914908 creator A5070321337 @default.
• W3003914908 creator A5084867053 @default.
• W3003914908 date "2020-09-01" @default.
• W3003914908 modified "2023-09-24" @default.
• W3003914908 title "Pharmacokinetics of Faster and Standard Insulin Aspart During Fully Closed-Loop Insulin Delivery in Type 2 Diabetes" @default.
• W3003914908 cites W1560129395 @default.
• W3003914908 cites W2040746407 @default.
• W3003914908 cites W2041489038 @default.
• W3003914908 cites W2043418796 @default.
• W3003914908 cites W2046390876 @default.
• W3003914908 cites W2049124610 @default.
• W3003914908 cites W2052199249 @default.
• W3003914908 cites W2078687483 @default.
• W3003914908 cites W2078985805 @default.
• W3003914908 cites W2084807168 @default.
• W3003914908 cites W2090964222 @default.
• W3003914908 cites W2130738181 @default.
• W3003914908 cites W2133581031 @default.
• W3003914908 cites W2529414368 @default.
• W3003914908 cites W2587826249 @default.
• W3003914908 cites W2743427221 @default.
• W3003914908 cites W2903866003 @default.
• W3003914908 cites W2913265488 @default.
• W3003914908 cites W2944369709 @default.
• W3003914908 cites W2944768911 @default.
• W3003914908 cites W2970369600 @default.
• W3003914908 cites W2978408390 @default.
• W3003914908 cites W4253023439 @default.
• W3003914908 doi "https://doi.org/10.1089/dia.2019.0477" @default.
• W3003914908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31999478" @default.
• W3003914908 hasPublicationYear "2020" @default.
• W3003914908 type Work @default.
• W3003914908 sameAs 3003914908 @default.
• W3003914908 citedByCount "3" @default.
• W3003914908 countsByYear W30039149082020 @default.
• W3003914908 countsByYear W30039149082021 @default.
• W3003914908 crossrefType "journal-article" @default.
• W3003914908 hasAuthorship W3003914908A5012170772 @default.
• W3003914908 hasAuthorship W3003914908A5017090852 @default.
• W3003914908 hasAuthorship W3003914908A5018676268 @default.
• W3003914908 hasAuthorship W3003914908A5018957018 @default.
• W3003914908 hasAuthorship W3003914908A5028753329 @default.
• W3003914908 hasAuthorship W3003914908A5070321337 @default.
• W3003914908 hasAuthorship W3003914908A5084867053 @default.
• W3003914908 hasBestOaLocation W30039149082 @default.
• W3003914908 hasConcept C112705442 @default.
• W3003914908 hasConcept C126322002 @default.
• W3003914908 hasConcept C134018914 @default.
• W3003914908 hasConcept C142724271 @default.
• W3003914908 hasConcept C204787440 @default.
• W3003914908 hasConcept C27081682 @default.
• W3003914908 hasConcept C2776486108 @default.
• W3003914908 hasConcept C2777180221 @default.
• W3003914908 hasConcept C2778199505 @default.
• W3003914908 hasConcept C2779306644 @default.
• W3003914908 hasConcept C2779908123 @default.
• W3003914908 hasConcept C2781232474 @default.
• W3003914908 hasConcept C555293320 @default.
• W3003914908 hasConcept C71924100 @default.
• W3003914908 hasConcept C87813604 @default.
• W3003914908 hasConceptScore W3003914908C112705442 @default.
• W3003914908 hasConceptScore W3003914908C126322002 @default.
• W3003914908 hasConceptScore W3003914908C134018914 @default.
• W3003914908 hasConceptScore W3003914908C142724271 @default.
• W3003914908 hasConceptScore W3003914908C204787440 @default.
• W3003914908 hasConceptScore W3003914908C27081682 @default.
• W3003914908 hasConceptScore W3003914908C2776486108 @default.
• W3003914908 hasConceptScore W3003914908C2777180221 @default.
• W3003914908 hasConceptScore W3003914908C2778199505 @default.
• W3003914908 hasConceptScore W3003914908C2779306644 @default.
• W3003914908 hasConceptScore W3003914908C2779908123 @default.
• W3003914908 hasConceptScore W3003914908C2781232474 @default.
• W3003914908 hasConceptScore W3003914908C555293320 @default.
• W3003914908 hasConceptScore W3003914908C71924100 @default.
• W3003914908 hasConceptScore W3003914908C87813604 @default.
• W3003914908 hasIssue "9" @default.
• W3003914908 hasLocation W30039149081 @default.
• W3003914908 hasLocation W30039149082 @default.
• W3003914908 hasLocation W30039149083 @default.
• W3003914908 hasOpenAccess W3003914908 @default.
• W3003914908 hasPrimaryLocation W30039149081 @default.
• W3003914908 hasRelatedWork W1553318551 @default.
• W3003914908 hasRelatedWork W1988541637 @default.
• W3003914908 hasRelatedWork W2017485364 @default.
• W3003914908 hasRelatedWork W2058579165 @default.
• W3003914908 hasRelatedWork W2080135029 @default.
• W3003914908 hasRelatedWork W2121580155 @default.
• W3003914908 hasRelatedWork W2129737421 @default.
• W3003914908 hasRelatedWork W2150944287 @default.
• W3003914908 hasRelatedWork W2153745306 @default.
• W3003914908 hasRelatedWork W3023693589 @default.

• next