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- W3003973921 abstract "A learning mechanism in the striatum An intriguing characteristic of the striatum is the random spatial distribution and high degree of intermingling between expression of dopamine receptor types 1 (D1) and 2 (D2) within striatal projection neurons (SPNs). The resulting highly entropic mosaic extends through a homogeneous space and is mostly devoid of histological boundaries. The rules established locally by D1- and D2-expressing SPNs (D1-SPNs and D2-SPNs) are thus likely critical in defining how functional territories develop throughout the striatum. Matamales et al. found that activated D2-SPNs access and modify developing behavioral programs encoded by regionally defined ensembles of transcriptionally active D1-SPNs. This process is slow because it depends on the molecular integration of additive neuro-modulatory signals. However, with time, it creates the regional functional boundaries that are necessary to identify and shape specific learning in the striatum. Science , this issue p. 549" @default.
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- W3003973921 date "2020-01-31" @default.
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- W3003973921 title "Local D2- to D1-neuron transmodulation updates goal-directed learning in the striatum" @default.
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- W3003973921 doi "https://doi.org/10.1126/science.aaz5751" @default.
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