FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003988637> ?p ?o ?g. }

• W3003988637 endingPage "126065" @default.
• W3003988637 startingPage "126065" @default.
• W3003988637 abstract "Two isoforms of Glutathione S-Transferase (GST) genes, belonging to mu (Dp-GSTm1 and Dp-GSTm2) and sigma (Dp-GSTs1 and Dp-GSTs2) classes, were cloned and characterised in the freshwater Daphnia pulex. No signal peptide was found in any of the four GST proteins, indicating that they were cytosolic GST. A highly conserved glutathione (GSH) binding site (G-site) occurred in the N-terminal sequence, and a substrate binding site (H-site), interacting non-specifically with the second hydrophobic substrate, was present in the C-terminal. A Tyr residue, for the stabilization of GSH, was found to be conserved in the analysed sequences. The secondary and tertiary structures indicated that these genes possess the typical cytosolic GST structure, including a conserved N-terminal domain with a βαβαββα motif. The μ loop (NVGPAPDYDR and NFIGAEWDR in Dp-GSTm1 and Dp-GSTm2, respectively) was identified between the βαβ (β1α1β2) and αββα motifs (α2β3β4α3) in the N-terminal domain. The expressions of Dp-GSTs1, Dp-GSTs2, and Dp-GSTm1 were higher in other age groups compared to the newly-born neonates (1 d); however, the expression of Dp-GSTm2 first increased and then decreased with age. Gene expression was significantly reduced by high concentration (1 and 2 mg/L) of 75 nm polystyrene nanoplastic. However, nanoplastic exposure at the predicted environmental concentration (1 μg/L) had a low effect. Exposure of mothers to nanoplastic (1 μg/L) elevated the Dp-GSTs2 level in their neonates. These results improve our understanding on the response of different types of Daphnid GST to environmental contaminants, especially nanoplastic." @default.
• W3003988637 created "2020-02-07" @default.
• W3003988637 creator A5004449255 @default.
• W3003988637 creator A5006764076 @default.
• W3003988637 creator A5008941160 @default.
• W3003988637 creator A5015275848 @default.
• W3003988637 creator A5018365310 @default.
• W3003988637 creator A5051762452 @default.
• W3003988637 creator A5068816814 @default.
• W3003988637 creator A5073212256 @default.
• W3003988637 creator A5076985010 @default.
• W3003988637 date "2020-06-01" @default.
• W3003988637 modified "2023-10-11" @default.
• W3003988637 title "Two sigma and two mu class genes of glutathione S-transferase in the waterflea Daphnia pulex: Molecular characterization and transcriptional response to nanoplastic exposure" @default.
• W3003988637 cites W1964568331 @default.
• W3003988637 cites W1977643106 @default.
• W3003988637 cites W1991342130 @default.
• W3003988637 cites W1992548175 @default.
• W3003988637 cites W2010884384 @default.
• W3003988637 cites W2023036866 @default.
• W3003988637 cites W2023287483 @default.
• W3003988637 cites W2027608202 @default.
• W3003988637 cites W2030842210 @default.
• W3003988637 cites W2036214554 @default.
• W3003988637 cites W2037205413 @default.
• W3003988637 cites W2043127992 @default.
• W3003988637 cites W2051600102 @default.
• W3003988637 cites W2059367834 @default.
• W3003988637 cites W2062780428 @default.
• W3003988637 cites W2067580458 @default.
• W3003988637 cites W2071114220 @default.
• W3003988637 cites W2079489819 @default.
• W3003988637 cites W2080234655 @default.
• W3003988637 cites W2085035392 @default.
• W3003988637 cites W2086534923 @default.
• W3003988637 cites W2087854507 @default.
• W3003988637 cites W2099481400 @default.
• W3003988637 cites W2101626712 @default.
• W3003988637 cites W2109636763 @default.
• W3003988637 cites W2110954875 @default.
• W3003988637 cites W2111713188 @default.
• W3003988637 cites W2116961566 @default.
• W3003988637 cites W2134241075 @default.
• W3003988637 cites W2143955569 @default.
• W3003988637 cites W2171791920 @default.
• W3003988637 cites W2302886330 @default.
• W3003988637 cites W2319381398 @default.
• W3003988637 cites W2395489634 @default.
• W3003988637 cites W2413261018 @default.
• W3003988637 cites W2415429249 @default.
• W3003988637 cites W2462387182 @default.
• W3003988637 cites W2505775939 @default.
• W3003988637 cites W2605932959 @default.
• W3003988637 cites W2793065554 @default.
• W3003988637 cites W2795645581 @default.
• W3003988637 cites W2801229377 @default.
• W3003988637 cites W2809908391 @default.
• W3003988637 cites W2888154153 @default.
• W3003988637 cites W2888234913 @default.
• W3003988637 cites W2894631038 @default.
• W3003988637 cites W2912453742 @default.
• W3003988637 cites W2913268981 @default.
• W3003988637 cites W2926284976 @default.
• W3003988637 cites W2936881263 @default.
• W3003988637 cites W2940004883 @default.
• W3003988637 cites W2945273538 @default.
• W3003988637 cites W2946333424 @default.
• W3003988637 cites W2951555632 @default.
• W3003988637 cites W2953735396 @default.
• W3003988637 cites W2968310455 @default.
• W3003988637 cites W2972727278 @default.
• W3003988637 cites W2982618489 @default.
• W3003988637 cites W2989520321 @default.
• W3003988637 cites W4238260078 @default.
• W3003988637 cites W4253184976 @default.
• W3003988637 doi "https://doi.org/10.1016/j.chemosphere.2020.126065" @default.
• W3003988637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32045975" @default.
• W3003988637 hasPublicationYear "2020" @default.
• W3003988637 type Work @default.
• W3003988637 sameAs 3003988637 @default.
• W3003988637 citedByCount "26" @default.
• W3003988637 countsByYear W30039886372020 @default.
• W3003988637 countsByYear W30039886372021 @default.
• W3003988637 countsByYear W30039886372022 @default.
• W3003988637 countsByYear W30039886372023 @default.
• W3003988637 crossrefType "journal-article" @default.
• W3003988637 hasAuthorship W3003988637A5004449255 @default.
• W3003988637 hasAuthorship W3003988637A5006764076 @default.
• W3003988637 hasAuthorship W3003988637A5008941160 @default.
• W3003988637 hasAuthorship W3003988637A5015275848 @default.
• W3003988637 hasAuthorship W3003988637A5018365310 @default.
• W3003988637 hasAuthorship W3003988637A5051762452 @default.
• W3003988637 hasAuthorship W3003988637A5068816814 @default.
• W3003988637 hasAuthorship W3003988637A5073212256 @default.
• W3003988637 hasAuthorship W3003988637A5076985010 @default.
• W3003988637 hasConcept C104317684 @default.
• W3003988637 hasConcept C107824862 @default.
• W3003988637 hasConcept C119795356 @default.

• next