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- W3004035603 abstract "The goal of this review is to pinpoint the specific features, including the weaknesses, of various tumor models, and to discuss the reasons why treatments that are efficient in murine tumor models often do not work in clinics. In a detailed comparison of transplanted and spontaneous tumor models, we focus on structure–function relationships in the tumor microenvironment. For instance, the architecture of the vascular tree, which depends on whether tumor cells have gone through epithelial-mesenchymal transition, is determinant for the extension of the spontaneous necrosis, and for the intratumoral localization of the immune infiltrate. Another key point is the model-dependent abundance of TGFβ in the tumor, which controls the variable susceptibility of different tumor models to treatments. Grounded in a historical perspective, this review provides a rationale for checking factors that will be key for the transition between preclinical murine models and clinical applications." @default.
- W3004035603 created "2020-02-07" @default.
- W3004035603 creator A5003819844 @default.
- W3004035603 creator A5020180300 @default.
- W3004035603 creator A5058059268 @default.
- W3004035603 creator A5074855451 @default.
- W3004035603 creator A5082501592 @default.
- W3004035603 date "2020-01-28" @default.
- W3004035603 modified "2023-10-01" @default.
- W3004035603 title "Preclinical murine tumor models: A structural and functional perspective" @default.
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