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• W3004050930 abstract "The RAG1-RAG2 recombinase (RAG) cleaves DNA to initiate V(D)J recombination, but RAG also belongs to the RNH-type transposase family. To learn how RAG-catalyzed transposition is inhibited in developing lymphocytes, we determined the structure of a DNA-strand transfer complex of mouse RAG at 3.1-Å resolution. The target DNA is a T form (T for transpositional target), which contains two >80° kinks towards the minor groove, only 3 bp apart. RAG2, a late evolutionary addition in V(D)J recombination, appears to enforce the sharp kinks and additional inter-segment twisting in target DNA and thus attenuates unwanted transposition. In contrast to strand transfer complexes of genuine transposases, where severe kinks occur at the integration sites of target DNA and thus prevent the reverse reaction, the sharp kink with RAG is 1 bp away from the integration site. As a result, RAG efficiently catalyzes the disintegration reaction that restores the RSS (donor) and target DNA. Structural elucidation of the RAG strand transfer complex reveals how the recombinase efficiently catalyzes both forward and reverse integration reactions to prevent RAG-mediated transposition events." @default.
• W3004050930 created "2020-02-07" @default.
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• W3004050930 date "2020-02-01" @default.
• W3004050930 modified "2023-10-17" @default.
• W3004050930 title "How mouse RAG recombinase avoids DNA transposition" @default.
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• W3004050930 doi "https://doi.org/10.1038/s41594-019-0366-z" @default.
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