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- W3004080558 abstract "Peritoneal metastasis is the second leading cause of death of colorectal cancer patients. Cytoreductive surgery (CRS) combined with hyperthermia intraperitoneal chemotherapy (HIPEC) is the primary method to treat peritoneal metastasis of colorectal cancer, though there remain some controversies. We reviewed current studies of colorectal peritoneal carcinomatosis (PC) and CRS+ HIPEC, and discussed some issues with regard to the scoring system for peritoneal metastasis, selection criteria for CRS+ HIPEC treatment, and the new drug application for colorectal PC. Peritoneal carcinomatosis index (PCI) is the most useful scoring system for peritoneal metastasis and CRS+ HIPEC is the primary treatment for colorectal PC. Patients with PCI<20 should receive thorough assessment on the feasibility of R0 or R1 resection and CRS+ HIPEC treatment. For patients with unresectable PC at the initial stage, active drug therapy should be adopted to achieve tumor regression, so that some of them would have the opportunity to receive CRS+ HIPEC treatment.腹膜转移是结直肠癌患者的第二大死亡原因。肿瘤细胞减灭术联合腹腔热灌注化疗(CRS＋HIPEC)是目前治疗结直肠癌腹膜转移的主要方法，但是仍存在着一定争议。本文回顾了结直肠癌腹膜转移和CRS＋HIPEC的相关研究，对腹膜转移评分体系(PCI)、CRS＋HIPEC的病例选择标准、CRS＋HIPEC的治疗方案争议，以及新的药物应用对于结直肠癌腹膜转移治疗影响等方面进行了论述。PCI评分是目前最适用于腹膜转移癌评估的临床标准，CRS＋HIPEC方案是结直肠癌腹膜转移的主要治疗手段。对于PCI<20分且有望实现R0或R1切除的患者应仔细评估，争取开展CRS＋HIPEC；对于初始不可切除的患者，积极的药物治疗或可使部分肿瘤转变为可能实现R0或R1切除的肿瘤，从而有机会接受CRS＋HIPEC治疗。." @default.
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- W3004080558 date "2018-08-01" @default.
- W3004080558 modified "2023-10-18" @default.
- W3004080558 title "[Treatment for peritoneal metastasis of colorectal cancer]." @default.
- W3004080558 doi "https://doi.org/10.3760/cma.j.issn.0529-5815.2018.08.003" @default.
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