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• W3004114334 abstract "Defects in the retina or the anterior segment of the eye lead to compromised vision and affect millions of people. Understanding how these ocular structures develop and are maintained is therefore of paramount importance. The maintenance of proper vision depends, among others, on the function of genes controlling apico-basal polarity. In fact, mutations in polarity genes are linked to retinal degeneration in several species, including human. Here we describe a novel zebrafish crb2b allele (crb2be40), which specifically affects the crb2b long isoform. crb2be40 mutants are viable and display normal ocular development. However, old crb2be40 mutant fish develop multiple defects in structures of the anterior segment, which includes the cornea, the iris and the lens. Phenotypes are characterised by smaller pupils due to expansion of the iris and tissues of the iridocorneal angle, an increased number of corneal stromal keratocytes, an abnormal corneal endothelium and an expanded lens capsule. These findings illustrate a novel role for crb2b in the maintenance of the anterior segment and hence add an important function to this polarity regulator, which may be conserved in other vertebrates, including humans." @default.
• W3004114334 created "2020-02-07" @default.
• W3004114334 creator A5002595262 @default.
• W3004114334 creator A5031959067 @default.
• W3004114334 creator A5035824972 @default.
• W3004114334 creator A5051504986 @default.
• W3004114334 creator A5055110576 @default.
• W3004114334 creator A5079601477 @default.
• W3004114334 date "2020-01-01" @default.
• W3004114334 modified "2023-10-14" @default.
• W3004114334 title "Loss of Crb2b-lf leads to anterior segment defects in old zebrafish" @default.
• W3004114334 cites W1558524165 @default.
• W3004114334 cites W163811931 @default.
• W3004114334 cites W1864853872 @default.
• W3004114334 cites W1963808262 @default.
• W3004114334 cites W1964018236 @default.
• W3004114334 cites W1964057962 @default.
• W3004114334 cites W1971566808 @default.
• W3004114334 cites W1972757014 @default.
• W3004114334 cites W1974328594 @default.
• W3004114334 cites W1975083495 @default.
• W3004114334 cites W1978529094 @default.
• W3004114334 cites W1979831998 @default.
• W3004114334 cites W1980670800 @default.
• W3004114334 cites W1982645824 @default.
• W3004114334 cites W1988935007 @default.
• W3004114334 cites W1989040340 @default.
• W3004114334 cites W1991397157 @default.
• W3004114334 cites W1993236121 @default.
• W3004114334 cites W1995358318 @default.
• W3004114334 cites W1996609490 @default.
• W3004114334 cites W1997927831 @default.
• W3004114334 cites W1998662169 @default.
• W3004114334 cites W2008034488 @default.
• W3004114334 cites W2009766076 @default.
• W3004114334 cites W2016767392 @default.
• W3004114334 cites W2023995963 @default.
• W3004114334 cites W2024646025 @default.
• W3004114334 cites W2035359474 @default.
• W3004114334 cites W2038509141 @default.
• W3004114334 cites W2041160349 @default.
• W3004114334 cites W2041186530 @default.
• W3004114334 cites W2043272632 @default.
• W3004114334 cites W2043498999 @default.
• W3004114334 cites W2045492894 @default.
• W3004114334 cites W2045936481 @default.
• W3004114334 cites W2050627372 @default.
• W3004114334 cites W2052254968 @default.
• W3004114334 cites W2060899505 @default.
• W3004114334 cites W2063658048 @default.
• W3004114334 cites W2063949796 @default.
• W3004114334 cites W2066103922 @default.
• W3004114334 cites W2068458175 @default.
• W3004114334 cites W2069669643 @default.
• W3004114334 cites W2074929099 @default.
• W3004114334 cites W2075321187 @default.
• W3004114334 cites W2078387059 @default.
• W3004114334 cites W2079210215 @default.
• W3004114334 cites W2081089031 @default.
• W3004114334 cites W2084097381 @default.
• W3004114334 cites W2101192001 @default.
• W3004114334 cites W2103136993 @default.
• W3004114334 cites W2103500143 @default.
• W3004114334 cites W2104455852 @default.
• W3004114334 cites W2108701018 @default.
• W3004114334 cites W2110178349 @default.
• W3004114334 cites W2112980158 @default.
• W3004114334 cites W2117876140 @default.
• W3004114334 cites W2120872799 @default.
• W3004114334 cites W2123787611 @default.
• W3004114334 cites W2124324528 @default.
• W3004114334 cites W2125349610 @default.
• W3004114334 cites W2133481779 @default.
• W3004114334 cites W2134764455 @default.
• W3004114334 cites W2145554185 @default.
• W3004114334 cites W2150132566 @default.
• W3004114334 cites W2152352220 @default.
• W3004114334 cites W2152641758 @default.
• W3004114334 cites W2158624339 @default.
• W3004114334 cites W2161930851 @default.
• W3004114334 cites W2167279371 @default.
• W3004114334 cites W2168572942 @default.
• W3004114334 cites W2168915088 @default.
• W3004114334 cites W2195220474 @default.
• W3004114334 cites W2272665634 @default.
• W3004114334 cites W2342251981 @default.
• W3004114334 cites W2400424890 @default.
• W3004114334 cites W2411554054 @default.
• W3004114334 cites W2426023477 @default.
• W3004114334 cites W2507590804 @default.
• W3004114334 cites W2511047441 @default.
• W3004114334 cites W2537731554 @default.
• W3004114334 cites W2588303991 @default.
• W3004114334 cites W2599964930 @default.
• W3004114334 cites W2605119664 @default.
• W3004114334 cites W2605273574 @default.
• W3004114334 cites W2606350525 @default.
• W3004114334 cites W2752504990 @default.
• W3004114334 cites W2766297399 @default.
• W3004114334 cites W2768045894 @default.

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