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- W3004176010 abstract "Cell division without growth results in progressive cell size reductions during early embryonic development. How do the sizes of intracellular structures and organelles scale with cell size and what are the functional implications of such scaling relationships? Model organisms, in particular Caenorhabditis elegans worms, Drosophila melanogaster flies, Xenopus laevis frogs, and Mus musculus mice, have provided insights into developmental size scaling of the nucleus, mitotic spindle, and chromosomes. Nuclear size is regulated by nucleocytoplasmic transport, nuclear envelope proteins, and the cytoskeleton. Regulators of microtubule dynamics and chromatin compaction modulate spindle and mitotic chromosome size scaling, respectively. Developmental scaling relationships for membrane-bound organelles, like the endoplasmic reticulum, Golgi, mitochondria, and lysosomes, have been less studied, although new imaging approaches promise to rectify this deficiency. While models that invoke limiting components and dynamic regulation of assembly and disassembly can account for some size scaling relationships in early embryos, it will be exciting to investigate the contribution of newer concepts in cell biology such as phase separation and interorganellar contacts. With a growing understanding of the underlying mechanisms of organelle size scaling, future studies promise to uncover the significance of proper scaling for cell function and embryonic development, as well as how aberrant scaling contributes to disease. This article is categorized under: Establishment of Spatial and Temporal Patterns > Regulation of Size, Proportion, and Timing Early Embryonic Development > Fertilization to Gastrulation Comparative Development and Evolution > Model Systems." @default.
- W3004176010 created "2020-02-07" @default.
- W3004176010 creator A5004303189 @default.
- W3004176010 creator A5039661320 @default.
- W3004176010 creator A5057865702 @default.
- W3004176010 date "2020-01-31" @default.
- W3004176010 modified "2023-10-16" @default.
- W3004176010 title "Organelle size scaling over embryonic development" @default.
- W3004176010 cites W1499511144 @default.
- W3004176010 cites W1501468947 @default.
- W3004176010 cites W1507819507 @default.
- W3004176010 cites W1523637635 @default.
- W3004176010 cites W1566724399 @default.
- W3004176010 cites W1581941249 @default.
- W3004176010 cites W1601755300 @default.
- W3004176010 cites W1606409542 @default.
- W3004176010 cites W1870115160 @default.
- W3004176010 cites W1904395290 @default.
- W3004176010 cites W1936657395 @default.
- W3004176010 cites W1963175326 @default.
- W3004176010 cites W1965404941 @default.
- W3004176010 cites W1965792464 @default.
- W3004176010 cites W1972897139 @default.
- W3004176010 cites W1973679647 @default.
- W3004176010 cites W1977275853 @default.
- W3004176010 cites W1977603207 @default.
- W3004176010 cites W1978908359 @default.
- W3004176010 cites W1981667961 @default.
- W3004176010 cites W1985681646 @default.
- W3004176010 cites W1986851724 @default.
- W3004176010 cites W1990891770 @default.
- W3004176010 cites W1992294145 @default.
- W3004176010 cites W1995586942 @default.
- W3004176010 cites W1995841941 @default.
- W3004176010 cites W1995891092 @default.
- W3004176010 cites W1997342202 @default.
- W3004176010 cites W1997509018 @default.
- W3004176010 cites W1997841095 @default.
- W3004176010 cites W1998485219 @default.
- W3004176010 cites W2001442551 @default.
- W3004176010 cites W2003250511 @default.
- W3004176010 cites W2004954151 @default.
- W3004176010 cites W2005733184 @default.
- W3004176010 cites W2010399610 @default.
- W3004176010 cites W2010662008 @default.
- W3004176010 cites W2013775624 @default.
- W3004176010 cites W2014964052 @default.
- W3004176010 cites W2016262076 @default.
- W3004176010 cites W2020609473 @default.
- W3004176010 cites W2021944123 @default.
- W3004176010 cites W2025140711 @default.
- W3004176010 cites W2026226960 @default.
- W3004176010 cites W2026669341 @default.
- W3004176010 cites W2026862467 @default.
- W3004176010 cites W2028630156 @default.
- W3004176010 cites W2031506646 @default.
- W3004176010 cites W2032532142 @default.
- W3004176010 cites W2033097911 @default.
- W3004176010 cites W2034617685 @default.
- W3004176010 cites W2035835061 @default.
- W3004176010 cites W2038385761 @default.
- W3004176010 cites W2040377035 @default.
- W3004176010 cites W2043039094 @default.
- W3004176010 cites W2043323445 @default.
- W3004176010 cites W2048439293 @default.
- W3004176010 cites W2051723944 @default.
- W3004176010 cites W2051965634 @default.
- W3004176010 cites W2052611780 @default.
- W3004176010 cites W2057813316 @default.
- W3004176010 cites W2059688507 @default.
- W3004176010 cites W2060020460 @default.
- W3004176010 cites W2061535202 @default.
- W3004176010 cites W2064304660 @default.
- W3004176010 cites W2064445525 @default.
- W3004176010 cites W2067400382 @default.
- W3004176010 cites W2068843391 @default.
- W3004176010 cites W2069362319 @default.
- W3004176010 cites W2069630707 @default.
- W3004176010 cites W2070210672 @default.
- W3004176010 cites W2070325295 @default.
- W3004176010 cites W2071059178 @default.
- W3004176010 cites W2074536102 @default.
- W3004176010 cites W2076507262 @default.
- W3004176010 cites W2077145482 @default.
- W3004176010 cites W2078032922 @default.
- W3004176010 cites W2078768877 @default.
- W3004176010 cites W2079422405 @default.
- W3004176010 cites W2081180790 @default.
- W3004176010 cites W2091241169 @default.
- W3004176010 cites W2092226243 @default.
- W3004176010 cites W2092855542 @default.
- W3004176010 cites W2095029801 @default.
- W3004176010 cites W2095617425 @default.
- W3004176010 cites W2095734482 @default.
- W3004176010 cites W2096927625 @default.
- W3004176010 cites W2097005988 @default.
- W3004176010 cites W2103593616 @default.
- W3004176010 cites W2105119391 @default.
- W3004176010 cites W2106114441 @default.
- W3004176010 cites W2108185984 @default.