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• W3004240469 abstract "Abstract Sequential immunization with antigens from different strains of HIV‐1, influenza viruses or dengue viruses induced cross‐neutralizing antibodies and enhanced the antibody responses against previous antigens. The characteristics of neutralizing antibodies induced by sequential immunization with different types of human papillomavirus (HPV) L1 virus‐like particles (L1VLPs) are unclear. In this study, mice were primed with one or two types (HPV‐16 or HPV16/18) of L1VLPs, then boosted sequentially with HPV6/18/45/11/31/58 or HPV6/45/11/31/58 L1VLPs, and sera were analyzed with HPV pseudovirus‐based neutralization assay. The results showed that neutralizing activities against earlier immunized vaccine types were enhanced gradually by subsequent immunizations, and low levels of neutralizing activities against nonvaccine types (HPV33/35/52/59/68) were also observed. After absorbing the immune sera with vaccine‐type (HPV16/18/45) L1VLPs, neutralizing activities against tested priming and boosting types (HPV16/18/58) decreased significantly, and that against nonvaccine type (HPV‐33) was also partially eliminated. Moreover, neutralizing activities against vaccine types (HPV16/58) were significantly reduced after absorbing with nonvaccine‐type VLPs (HPV33/52). These data suggest that cross‐neutralizing epitopes exist among different HPV L1VLPs. The cross‐neutralizing activities against nonvaccine types and the enhanced neutralizing activities against earlier immunized vaccine types may result from sequential boosting with these cross‐neutralizing epitopes. These observations support early vaccination with more types of L1VLPs derived from HPVs that cause a serious threat to the population." @default.
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• W3004240469 date "2020-02-19" @default.
• W3004240469 modified "2023-10-01" @default.
• W3004240469 title "Induction of cross‐neutralizing antibodies by sequential immunization with heterologous papillomavirus L1VLPs and its implications for HPV prophylactic vaccines" @default.
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• W3004240469 doi "https://doi.org/10.1002/jmv.25690" @default.
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