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• W3004251285 abstract "Abstract Argonaute proteins and their interacting small RNAs play a key role in regulating complementary mRNA targets during animal development. Here, we investigate a novel and essential function of the catalytically active Argonaute protein CSR-1 in maternal mRNA degradation during early embryogenesis in Caenorhabditis elegans. We show that CSR-1 interacts with endogenous small RNAs antisense to hundreds of cleared maternal mRNAs in embryos, and preferentially cleaves mRNAs no longer engaged in translation. The depletion of CSR-1 during maternal to zygotic transition leads to embryonic lethality in a catalytic-dependent manner and impairs the degradations of its embryonic mRNA targets. Given the conservation of Argonaute catalytic activity, we propose that a similar mechanism operate to clear maternal mRNAs during maternal to zygotic transition across species." @default.
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• W3004251285 date "2020-02-03" @default.
• W3004251285 modified "2023-09-25" @default.
• W3004251285 title "Argonaute catalytic activity is required for maternal mRNA clearance in embryos" @default.
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• W3004251285 hasPublicationYear "2020" @default.
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