FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004277162> ?p ?o ?g. }

• W3004277162 endingPage "19.2020" @default.
• W3004277162 startingPage "ENEURO.0339" @default.
• W3004277162 abstract "Abstract The Skn-1a transcription factor ( Pou2f3 ) is required for Type II taste cell differentiation in taste buds. Taste buds in Skn-1a -/- mice lack Type II taste cells but have a concomitant expansion of Type III cells, providing an ideal model to determine the relative role of taste cell types in response specificity. We confirmed that chorda tympani responses to sweet, bitter, and umami stimuli were greatly reduced in the knock-outs (KOs) compared with wild-type (WT) littermates. Skn-1a -/- mice also had reductions to NaCl that were partially amiloride-insensitive, suggesting that both Type II and Type III cells contribute to amiloride-insensitive salt detection in anterior tongue. We also confirmed that responses to sour stimuli are equivalent in the KOs, despite the large increase in the number of Type III taste cells. To examine their innervation, we crossed the Htr3a -GFP (5-HT 3A -GFP) reporter mouse with the Skn-1a -/- mice and examined geniculate ganglion neurons for GFP expression and responses to 5-HT. We found no change in the number of 5-HT 3A -expressing neurons with KO of Skn-1a . Calcium imaging showed that only 5-HT 3A -expressing neurons respond to exogenous 5-HT, while most neurons respond to ATP, similar to WT mice. Interestingly, despite loss of all Type II cells, the P2X3 antagonist AF353 blocked all chorda tympani responses. These data collectively raise questions pertaining the source of ATP signaling in the absence of Type II taste cells and whether the additional Type III cells are innervated by fibers that would have normally innervated Type II cells." @default.
• W3004277162 created "2020-02-07" @default.
• W3004277162 creator A5005343881 @default.
• W3004277162 creator A5060995309 @default.
• W3004277162 creator A5067950982 @default.
• W3004277162 creator A5072104625 @default.
• W3004277162 date "2020-01-01" @default.
• W3004277162 modified "2023-10-03" @default.
• W3004277162 title "Function, Innervation, and Neurotransmitter Signaling in Mice Lacking Type-II Taste Cells" @default.
• W3004277162 cites W1543725929 @default.
• W3004277162 cites W1549716303 @default.
• W3004277162 cites W1851564563 @default.
• W3004277162 cites W1971207325 @default.
• W3004277162 cites W1991274614 @default.
• W3004277162 cites W1994999924 @default.
• W3004277162 cites W2008002043 @default.
• W3004277162 cites W2014669864 @default.
• W3004277162 cites W2015608635 @default.
• W3004277162 cites W2020575571 @default.
• W3004277162 cites W2037948893 @default.
• W3004277162 cites W2046872526 @default.
• W3004277162 cites W2049038291 @default.
• W3004277162 cites W2055552160 @default.
• W3004277162 cites W2061534557 @default.
• W3004277162 cites W2067960353 @default.
• W3004277162 cites W2087151519 @default.
• W3004277162 cites W2091992230 @default.
• W3004277162 cites W2115156649 @default.
• W3004277162 cites W2118446318 @default.
• W3004277162 cites W2118912225 @default.
• W3004277162 cites W2121407171 @default.
• W3004277162 cites W2127578476 @default.
• W3004277162 cites W2169348175 @default.
• W3004277162 cites W2183262710 @default.
• W3004277162 cites W2235801130 @default.
• W3004277162 cites W2253659819 @default.
• W3004277162 cites W2345026496 @default.
• W3004277162 cites W2602898405 @default.
• W3004277162 cites W2731177171 @default.
• W3004277162 cites W2739714473 @default.
• W3004277162 cites W2749921010 @default.
• W3004277162 cites W2758667792 @default.
• W3004277162 cites W2787374358 @default.
• W3004277162 cites W2802984476 @default.
• W3004277162 cites W2951359509 @default.
• W3004277162 cites W2973570598 @default.
• W3004277162 cites W4238834309 @default.
• W3004277162 doi "https://doi.org/10.1523/eneuro.0339-19.2020" @default.
• W3004277162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7004487" @default.
• W3004277162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31988217" @default.
• W3004277162 hasPublicationYear "2020" @default.
• W3004277162 type Work @default.
• W3004277162 sameAs 3004277162 @default.
• W3004277162 citedByCount "16" @default.
• W3004277162 countsByYear W30042771622020 @default.
• W3004277162 countsByYear W30042771622021 @default.
• W3004277162 countsByYear W30042771622022 @default.
• W3004277162 countsByYear W30042771622023 @default.
• W3004277162 crossrefType "journal-article" @default.
• W3004277162 hasAuthorship W3004277162A5005343881 @default.
• W3004277162 hasAuthorship W3004277162A5060995309 @default.
• W3004277162 hasAuthorship W3004277162A5067950982 @default.
• W3004277162 hasAuthorship W3004277162A5072104625 @default.
• W3004277162 hasBestOaLocation W30042771621 @default.
• W3004277162 hasConcept C104317684 @default.
• W3004277162 hasConcept C126322002 @default.
• W3004277162 hasConcept C134018914 @default.
• W3004277162 hasConcept C142613039 @default.
• W3004277162 hasConcept C142724271 @default.
• W3004277162 hasConcept C143065580 @default.
• W3004277162 hasConcept C1491633281 @default.
• W3004277162 hasConcept C169760540 @default.
• W3004277162 hasConcept C178006227 @default.
• W3004277162 hasConcept C178790620 @default.
• W3004277162 hasConcept C185592680 @default.
• W3004277162 hasConcept C189014844 @default.
• W3004277162 hasConcept C204787440 @default.
• W3004277162 hasConcept C207583985 @default.
• W3004277162 hasConcept C2775871351 @default.
• W3004277162 hasConcept C2776946002 @default.
• W3004277162 hasConcept C2777687625 @default.
• W3004277162 hasConcept C2778097013 @default.
• W3004277162 hasConcept C2779608910 @default.
• W3004277162 hasConcept C2780833121 @default.
• W3004277162 hasConcept C537181965 @default.
• W3004277162 hasConcept C55493867 @default.
• W3004277162 hasConcept C71924100 @default.
• W3004277162 hasConcept C86803240 @default.
• W3004277162 hasConcept C8868529 @default.
• W3004277162 hasConcept C95444343 @default.
• W3004277162 hasConceptScore W3004277162C104317684 @default.
• W3004277162 hasConceptScore W3004277162C126322002 @default.
• W3004277162 hasConceptScore W3004277162C134018914 @default.
• W3004277162 hasConceptScore W3004277162C142613039 @default.
• W3004277162 hasConceptScore W3004277162C142724271 @default.
• W3004277162 hasConceptScore W3004277162C143065580 @default.
• W3004277162 hasConceptScore W3004277162C1491633281 @default.
• W3004277162 hasConceptScore W3004277162C169760540 @default.

• next