Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004340098> ?p ?o ?g. }
- W3004340098 abstract "Background: Cutaneous and mucocutaneous leishmaniasis are parasitic diseases characterized by skin manifestations. In Brazil, Leishmania (Leishmania) amazonensis is one of the etiological agents of cutaneous leishmaniasis. The therapeutic arsenal routinely employed to treat infected patients is unsatisfactory, especially for pentavalent antimonials, as they are often highly toxic, poorly tolerated and of variable effectiveness. This study aimed to evaluate in vitro the leishmanicidal activity of toxins isolated from Crotalus durissus terrificus venom as a new approach for the treatment of leishmaniasis. Methods: The comparative effects of crotamine, crotoxin, gyrotoxin, convulxin and PLA2 on bone marrow-derived macrophages infected with L. (L.) amazonensis as well as the release of TGF-β from the treated macrophages were studied. Results and Discussion: Crotamine had the strongest inhibitory effect on parasite growth rate (IC50: 25.65±0.52 μg/mL), while convulxin showed the weakest inhibitory effect (IC50: 52.7±2.21 μg/mL). In addition, TGF-β was significantly reduced after the treatment with all toxins evaluated. Conclusion: The Crotalus durissus terrificus toxins used in this study displayed significant activity against L. (L.) amazonensis, indicating that all of them could be a potential alternative for the treatment of cutaneous leishmaniasis." @default.
- W3004340098 created "2020-02-07" @default.
- W3004340098 creator A5020557294 @default.
- W3004340098 creator A5025985830 @default.
- W3004340098 creator A5050918052 @default.
- W3004340098 creator A5053396478 @default.
- W3004340098 creator A5069820863 @default.
- W3004340098 creator A5090625336 @default.
- W3004340098 date "2020-09-24" @default.
- W3004340098 modified "2023-10-12" @default.
- W3004340098 title "Effect of Isolated Proteins from Crotalus Durissus Terrificus Venom on Leishmania (Leishmania) Amazonensis-Infected Macrophages" @default.
- W3004340098 cites W1894181283 @default.
- W3004340098 cites W1981631429 @default.
- W3004340098 cites W1995164826 @default.
- W3004340098 cites W1995822392 @default.
- W3004340098 cites W2001611780 @default.
- W3004340098 cites W2008520486 @default.
- W3004340098 cites W2010084238 @default.
- W3004340098 cites W2011342199 @default.
- W3004340098 cites W2018956690 @default.
- W3004340098 cites W2029976352 @default.
- W3004340098 cites W2030863654 @default.
- W3004340098 cites W2030887495 @default.
- W3004340098 cites W2069927893 @default.
- W3004340098 cites W2079140747 @default.
- W3004340098 cites W2084323650 @default.
- W3004340098 cites W2094276362 @default.
- W3004340098 cites W2096786688 @default.
- W3004340098 cites W2102328887 @default.
- W3004340098 cites W2113949111 @default.
- W3004340098 cites W2118404178 @default.
- W3004340098 cites W2130706536 @default.
- W3004340098 cites W2158084302 @default.
- W3004340098 cites W2172266327 @default.
- W3004340098 cites W2214931040 @default.
- W3004340098 cites W2313430757 @default.
- W3004340098 cites W2592855024 @default.
- W3004340098 cites W2702812593 @default.
- W3004340098 cites W2791379921 @default.
- W3004340098 cites W2808036105 @default.
- W3004340098 cites W2808320850 @default.
- W3004340098 cites W4211073781 @default.
- W3004340098 doi "https://doi.org/10.2174/0929866527666200129152954" @default.
- W3004340098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31994997" @default.
- W3004340098 hasPublicationYear "2020" @default.
- W3004340098 type Work @default.
- W3004340098 sameAs 3004340098 @default.
- W3004340098 citedByCount "6" @default.
- W3004340098 countsByYear W30043400982020 @default.
- W3004340098 countsByYear W30043400982021 @default.
- W3004340098 countsByYear W30043400982022 @default.
- W3004340098 countsByYear W30043400982023 @default.
- W3004340098 crossrefType "journal-article" @default.
- W3004340098 hasAuthorship W3004340098A5020557294 @default.
- W3004340098 hasAuthorship W3004340098A5025985830 @default.
- W3004340098 hasAuthorship W3004340098A5050918052 @default.
- W3004340098 hasAuthorship W3004340098A5053396478 @default.
- W3004340098 hasAuthorship W3004340098A5069820863 @default.
- W3004340098 hasAuthorship W3004340098A5090625336 @default.
- W3004340098 hasConcept C136764020 @default.
- W3004340098 hasConcept C203014093 @default.
- W3004340098 hasConcept C2776555147 @default.
- W3004340098 hasConcept C2776725428 @default.
- W3004340098 hasConcept C2778702967 @default.
- W3004340098 hasConcept C2779448229 @default.
- W3004340098 hasConcept C2780331750 @default.
- W3004340098 hasConcept C2781092759 @default.
- W3004340098 hasConcept C2781371782 @default.
- W3004340098 hasConcept C41008148 @default.
- W3004340098 hasConcept C55493867 @default.
- W3004340098 hasConcept C71928629 @default.
- W3004340098 hasConcept C86803240 @default.
- W3004340098 hasConcept C89423630 @default.
- W3004340098 hasConcept C98274493 @default.
- W3004340098 hasConcept C98319499 @default.
- W3004340098 hasConceptScore W3004340098C136764020 @default.
- W3004340098 hasConceptScore W3004340098C203014093 @default.
- W3004340098 hasConceptScore W3004340098C2776555147 @default.
- W3004340098 hasConceptScore W3004340098C2776725428 @default.
- W3004340098 hasConceptScore W3004340098C2778702967 @default.
- W3004340098 hasConceptScore W3004340098C2779448229 @default.
- W3004340098 hasConceptScore W3004340098C2780331750 @default.
- W3004340098 hasConceptScore W3004340098C2781092759 @default.
- W3004340098 hasConceptScore W3004340098C2781371782 @default.
- W3004340098 hasConceptScore W3004340098C41008148 @default.
- W3004340098 hasConceptScore W3004340098C55493867 @default.
- W3004340098 hasConceptScore W3004340098C71928629 @default.
- W3004340098 hasConceptScore W3004340098C86803240 @default.
- W3004340098 hasConceptScore W3004340098C89423630 @default.
- W3004340098 hasConceptScore W3004340098C98274493 @default.
- W3004340098 hasConceptScore W3004340098C98319499 @default.
- W3004340098 hasFunder F4320320997 @default.
- W3004340098 hasLocation W30043400981 @default.
- W3004340098 hasOpenAccess W3004340098 @default.
- W3004340098 hasPrimaryLocation W30043400981 @default.
- W3004340098 hasRelatedWork W11531487 @default.
- W3004340098 hasRelatedWork W15960744 @default.
- W3004340098 hasRelatedWork W19572556 @default.
- W3004340098 hasRelatedWork W21919429 @default.
- W3004340098 hasRelatedWork W23098337 @default.