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- W3004396377 abstract "Abstract The establishment of protective humoral immunity is dependent on the ability of mature B cells to undergo antibody gene diversification while adjusting to the physiological stressors induced by activation with the antigen. Mature B cells diversify their antibody genes by class switch recombination (CSR) and somatic hypermutation (SHM), which are both dependent on efficient induction of activation-induced cytidine deaminase (AID). Here, we identified PDGFA-associated protein 1 (Pdap1) as an essential regulator of cellular homeostasis in mature B cells. Pdap1 deficiency leads to sustained expression of the integrated stress response (ISR) effector activating transcription factor 4 (Atf4) and induction of the ISR transcriptional program, increased cell death, and defective AID expression. As a consequence, loss of Pdap1 reduces germinal center B cell formation and impairs CSR and SHM. Thus, Pdap1 protects mature B cells against chronic ISR activation and ensures efficient antibody diversification by promoting their survival and optimal function." @default.
- W3004396377 created "2020-02-07" @default.
- W3004396377 creator A5000779575 @default.
- W3004396377 creator A5010122056 @default.
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- W3004396377 creator A5051357170 @default.
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- W3004396377 creator A5064554843 @default.
- W3004396377 creator A5090860833 @default.
- W3004396377 date "2020-01-31" @default.
- W3004396377 modified "2023-10-16" @default.
- W3004396377 title "Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification" @default.
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