FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004398085> ?p ?o ?g. }

• W3004398085 endingPage "1276" @default.
• W3004398085 startingPage "1267" @default.
• W3004398085 abstract "Abstract Purpose: The purpose of this study was to evaluate antigen experienced T cells in peripheral blood lymphocytes (PBL) for responses to p53 neoantigens. Experimental Design: PBLs from patients with a mutated TP53 tumor were sorted for antigen-experienced T cells and in vitro stimulation (IVS) was performed with p53 neoantigens. The IVS cultures were stimulated with antigen-presenting cells expressing p53 neoantigens, enriched for 41BB/OX40 and grown with rapid expansion protocol. Results: T-cell responses were not observed in the PBLs of 4 patients who did not have tumor-infiltrating lymphocyte (TIL) responses to mutated TP53. In contrast, 5 patients with TIL responses to mutated TP53 also had similar T-cell responses in their PBLs, indicating that the PBLs and TILs were congruent in p53 neoantigen reactivity. CD4+ and CD8+ T cells were specific for p53R175H, p53Y220C, or p53R248W neoantigens, including a 78% reactive T-cell culture against p53R175H and HLA-A*02:01. Tracking TCRB clonotypes (clonality, top ranked, and TP53 mutation-specific) supported the enrichment of p53 neoantigen–reactive T cells from PBLs. The same T-cell receptor (TCR) from the TIL was found in the IVS cultures in three cases and multiple unique TCRs were found in another patient. TP53 mutation–specific T cells also recognized tumor cell lines bearing the appropriate human leukocyte antigen restriction element and TP53 mutation, indicating these T cells could recognize processed and presented p53 neoantigens. Conclusions: PBL was a noninvasive source of T cells targeting TP53 mutations for cell therapy and can provide a window into intratumoral p53 neoantigen immune responses. See related commentary by Olivera et al., p. 1203" @default.
• W3004398085 created "2020-02-07" @default.
• W3004398085 creator A5003770095 @default.
• W3004398085 creator A5007307709 @default.
• W3004398085 creator A5012557494 @default.
• W3004398085 creator A5018045451 @default.
• W3004398085 creator A5019931229 @default.
• W3004398085 creator A5024701461 @default.
• W3004398085 creator A5031216154 @default.
• W3004398085 creator A5032718078 @default.
• W3004398085 creator A5038540992 @default.
• W3004398085 creator A5039151855 @default.
• W3004398085 creator A5051448151 @default.
• W3004398085 creator A5058077037 @default.
• W3004398085 creator A5058132822 @default.
• W3004398085 creator A5058198790 @default.
• W3004398085 creator A5061987607 @default.
• W3004398085 creator A5065870508 @default.
• W3004398085 creator A5072133376 @default.
• W3004398085 creator A5080035254 @default.
• W3004398085 creator A5085672385 @default.
• W3004398085 creator A5088617435 @default.
• W3004398085 creator A5091096889 @default.
• W3004398085 date "2020-03-13" @default.
• W3004398085 modified "2023-10-16" @default.
• W3004398085 title "Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens" @default.
• W3004398085 cites W1490351768 @default.
• W3004398085 cites W1893868216 @default.
• W3004398085 cites W1947715787 @default.
• W3004398085 cites W1966841369 @default.
• W3004398085 cites W1985278235 @default.
• W3004398085 cites W2013257892 @default.
• W3004398085 cites W2021472146 @default.
• W3004398085 cites W2069452349 @default.
• W3004398085 cites W2076948707 @default.
• W3004398085 cites W2080615724 @default.
• W3004398085 cites W2092073124 @default.
• W3004398085 cites W2095813207 @default.
• W3004398085 cites W2098098349 @default.
• W3004398085 cites W2102368462 @default.
• W3004398085 cites W2103077070 @default.
• W3004398085 cites W2110947069 @default.
• W3004398085 cites W2114786150 @default.
• W3004398085 cites W2120869188 @default.
• W3004398085 cites W2129676200 @default.
• W3004398085 cites W2132923173 @default.
• W3004398085 cites W2142081242 @default.
• W3004398085 cites W2148360952 @default.
• W3004398085 cites W2167339434 @default.
• W3004398085 cites W2201214180 @default.
• W3004398085 cites W2340751952 @default.
• W3004398085 cites W2395676613 @default.
• W3004398085 cites W2472697448 @default.
• W3004398085 cites W2529381231 @default.
• W3004398085 cites W2559953355 @default.
• W3004398085 cites W2607497548 @default.
• W3004398085 cites W2744428642 @default.
• W3004398085 cites W2758689089 @default.
• W3004398085 cites W2765694924 @default.
• W3004398085 cites W2767331838 @default.
• W3004398085 cites W2773476473 @default.
• W3004398085 cites W2793742921 @default.
• W3004398085 cites W2805363059 @default.
• W3004398085 cites W2806895459 @default.
• W3004398085 cites W2895264449 @default.
• W3004398085 cites W2912739653 @default.
• W3004398085 cites W2913440788 @default.
• W3004398085 cites W2913665794 @default.
• W3004398085 cites W2943226078 @default.
• W3004398085 cites W2948516395 @default.
• W3004398085 cites W2950859100 @default.
• W3004398085 cites W4234746319 @default.
• W3004398085 cites W4376848401 @default.
• W3004398085 doi "https://doi.org/10.1158/1078-0432.ccr-19-1874" @default.
• W3004398085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7424598" @default.
• W3004398085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31996390" @default.
• W3004398085 hasPublicationYear "2020" @default.
• W3004398085 type Work @default.
• W3004398085 sameAs 3004398085 @default.
• W3004398085 citedByCount "59" @default.
• W3004398085 countsByYear W30043980852020 @default.
• W3004398085 countsByYear W30043980852021 @default.
• W3004398085 countsByYear W30043980852022 @default.
• W3004398085 countsByYear W30043980852023 @default.
• W3004398085 crossrefType "journal-article" @default.
• W3004398085 hasAuthorship W3004398085A5003770095 @default.
• W3004398085 hasAuthorship W3004398085A5007307709 @default.
• W3004398085 hasAuthorship W3004398085A5012557494 @default.
• W3004398085 hasAuthorship W3004398085A5018045451 @default.
• W3004398085 hasAuthorship W3004398085A5019931229 @default.
• W3004398085 hasAuthorship W3004398085A5024701461 @default.
• W3004398085 hasAuthorship W3004398085A5031216154 @default.
• W3004398085 hasAuthorship W3004398085A5032718078 @default.
• W3004398085 hasAuthorship W3004398085A5038540992 @default.
• W3004398085 hasAuthorship W3004398085A5039151855 @default.
• W3004398085 hasAuthorship W3004398085A5051448151 @default.
• W3004398085 hasAuthorship W3004398085A5058077037 @default.
• W3004398085 hasAuthorship W3004398085A5058132822 @default.

• next