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- W3004417484 abstract "Surface tension is overwhelmed by pulmonary surfactant (PS) in the alveolar air-liquid interface in order to maintain operational breathing. PS essentially consists on an adsorbed lipid monolayer connected to a highly dynamic membrane reservoir that continuously nurtures the interface with newly synthesized PS-complexes. Due to respiratory mechanics, PS membranes are continuously undergoing an essential structural remodelling for stabilizing the respiratory air-liquid interface. Apart from lipids, two hydrophobic proteins play key roles in breathing homeostasis by interconnecting interfacial films and PS membranes: surfactant proteins B (SP-B) and C (SP-C). SP-B critically interacts with surfactant lipids and, though its structure has not resolved at atomic detail yet, it has been proposed to form oligomers assembled in the form of hydrophobic tubes through which surfactant lipids might flow towards the alveolar air-liquid interface. Furthermore, SP- C has been proposed to induce membrane curvature and promote selective exclusion of unsaturated surfactant lipids that cannot stand high surface pressure. Altogether, PS complexes form a particularly complex membrane network in alveolar spaces, subjected to the mechanical challenge of a continuous compression-expansion dynamics. Typically, the main approach to study PS has been the analysis of Langmuir monolayers and films by fluorescence microscopy and atomic force microscopy, limiting the structural study to PS monolayers or in static conditions. Here, we have performed neutron reflectometry experiments on FIGARO, a time-of-flight reflectometer, at the Institute Laue-Langevin (France), of adsorbed multilamellar complex surfactant films subjected to compression-expansion cycles in a Langmuir trough. By this methodology, not only were we able to obtain 2-D information concerning lipid compressibility and lipid-protein interactions, but also 3-D structures formed along compression-expansion cycles were detected." @default.
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- W3004417484 date "2020-02-01" @default.
- W3004417484 modified "2023-10-16" @default.
- W3004417484 title "Beyond the Monolayer: Pulmonary Surfactant Films Analysed by a Fluid-Interfaces-Grazing-Angles-Neutron-Reflectometer (FIGARO)" @default.
- W3004417484 doi "https://doi.org/10.1016/j.bpj.2019.11.2197" @default.
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