FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004420002> ?p ?o ?g. }

• W3004420002 endingPage "1111" @default.
• W3004420002 startingPage "1111" @default.
• W3004420002 abstract "Dexamethasone (Dex) has been widely used as a potent anti-inflammatory, antishock, and immunosuppressive agent. However, high dose or long-term use of Dex is accompanied by side effects including skeletal muscle atrophy, whose underlying mechanisms remain incompletely understood. A number of microRNAs (miRNAs) have been shown to play key roles in skeletal muscle atrophy. Previous studies showed significantly increased miR-322 expression in Dex-treated C2C12 myotubes. In our study, the glucocorticoid receptor (GR) was required for Dex to increase miR-322 expression in C2C12 myotubes. miR-322 mimic or miR-322 inhibitor was used for regulating the expression of miR-322. Insulin-like growth factor 1 receptor (IGF1R) and insulin receptor (INSR) were identified as target genes of miR-322 using luciferase reporter assays and played key roles in Dex-induced muscle atrophy. miR-322 overexpression promoted atrophy in Dex-treated C2C12 myotubes and the gastrocnemius muscles of mice. Conversely, miR-322 inhibition showed the opposite effects. These data suggested that miR-322 contributes to Dex-induced muscle atrophy via targeting of IGF1R and INSR. Furthermore, miR-322 might be a potential target to counter Dex-induced muscle atrophy. miR-322 inhibition might also represent a therapeutic approach for Dex-induced muscle atrophy." @default.
• W3004420002 created "2020-02-14" @default.
• W3004420002 creator A5015174638 @default.
• W3004420002 creator A5018685204 @default.
• W3004420002 creator A5032217220 @default.
• W3004420002 creator A5073429758 @default.
• W3004420002 creator A5079241101 @default.
• W3004420002 creator A5081311272 @default.
• W3004420002 creator A5085325895 @default.
• W3004420002 date "2020-02-07" @default.
• W3004420002 modified "2023-10-01" @default.
• W3004420002 title "MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by Targeting IGF1R and INSR" @default.
• W3004420002 cites W1568018271 @default.
• W3004420002 cites W1694750548 @default.
• W3004420002 cites W1818506670 @default.
• W3004420002 cites W1969249022 @default.
• W3004420002 cites W1990790857 @default.
• W3004420002 cites W1993476327 @default.
• W3004420002 cites W1996025648 @default.
• W3004420002 cites W2001982957 @default.
• W3004420002 cites W2003052916 @default.
• W3004420002 cites W2009256493 @default.
• W3004420002 cites W2014140012 @default.
• W3004420002 cites W2015448195 @default.
• W3004420002 cites W2016344437 @default.
• W3004420002 cites W2033797333 @default.
• W3004420002 cites W2036938071 @default.
• W3004420002 cites W2042524770 @default.
• W3004420002 cites W2047635605 @default.
• W3004420002 cites W2055810659 @default.
• W3004420002 cites W2059083151 @default.
• W3004420002 cites W2070345867 @default.
• W3004420002 cites W2093481377 @default.
• W3004420002 cites W2104473184 @default.
• W3004420002 cites W2104772248 @default.
• W3004420002 cites W2107960666 @default.
• W3004420002 cites W2122696263 @default.
• W3004420002 cites W2123631180 @default.
• W3004420002 cites W2128705420 @default.
• W3004420002 cites W2147015347 @default.
• W3004420002 cites W2149027898 @default.
• W3004420002 cites W2151917785 @default.
• W3004420002 cites W2161222316 @default.
• W3004420002 cites W2168020094 @default.
• W3004420002 cites W2213579467 @default.
• W3004420002 cites W2214045928 @default.
• W3004420002 cites W2234372933 @default.
• W3004420002 cites W2346376871 @default.
• W3004420002 cites W2400936627 @default.
• W3004420002 cites W2407917507 @default.
• W3004420002 cites W2513613066 @default.
• W3004420002 cites W2552394180 @default.
• W3004420002 cites W2620108944 @default.
• W3004420002 cites W2773551205 @default.
• W3004420002 cites W2789344096 @default.
• W3004420002 cites W2900846375 @default.
• W3004420002 cites W52893799 @default.
• W3004420002 cites W56816218 @default.
• W3004420002 doi "https://doi.org/10.3390/ijms21031111" @default.
• W3004420002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7043225" @default.
• W3004420002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32046161" @default.
• W3004420002 hasPublicationYear "2020" @default.
• W3004420002 type Work @default.
• W3004420002 sameAs 3004420002 @default.
• W3004420002 citedByCount "15" @default.
• W3004420002 countsByYear W30044200022020 @default.
• W3004420002 countsByYear W30044200022021 @default.
• W3004420002 countsByYear W30044200022022 @default.
• W3004420002 countsByYear W30044200022023 @default.
• W3004420002 crossrefType "journal-article" @default.
• W3004420002 hasAuthorship W3004420002A5015174638 @default.
• W3004420002 hasAuthorship W3004420002A5018685204 @default.
• W3004420002 hasAuthorship W3004420002A5032217220 @default.
• W3004420002 hasAuthorship W3004420002A5073429758 @default.
• W3004420002 hasAuthorship W3004420002A5079241101 @default.
• W3004420002 hasAuthorship W3004420002A5081311272 @default.
• W3004420002 hasAuthorship W3004420002A5085325895 @default.
• W3004420002 hasBestOaLocation W30044200021 @default.
• W3004420002 hasConcept C104317684 @default.
• W3004420002 hasConcept C126322002 @default.
• W3004420002 hasConcept C134018914 @default.
• W3004420002 hasConcept C144174609 @default.
• W3004420002 hasConcept C145059251 @default.
• W3004420002 hasConcept C170493617 @default.
• W3004420002 hasConcept C2775960820 @default.
• W3004420002 hasConcept C2776263037 @default.
• W3004420002 hasConcept C2779959927 @default.
• W3004420002 hasConcept C2780841215 @default.
• W3004420002 hasConcept C2781172350 @default.
• W3004420002 hasConcept C3763915 @default.
• W3004420002 hasConcept C55493867 @default.
• W3004420002 hasConcept C59493245 @default.
• W3004420002 hasConcept C60278653 @default.
• W3004420002 hasConcept C71924100 @default.
• W3004420002 hasConcept C86803240 @default.
• W3004420002 hasConceptScore W3004420002C104317684 @default.
• W3004420002 hasConceptScore W3004420002C126322002 @default.
• W3004420002 hasConceptScore W3004420002C134018914 @default.

• next