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- W3004428305 abstract "A programmable microfluidic platform enabling on-demand sampling, compartmentalization, and manipulation of multiple aqueous volumes is presented. The system provides random-access actuation of a microtrap array supporting selective discretization of picoliter volumes from multiple sample inputs. The platform comprises two interconnected chips, with parallel T-junctions and multiplexed microvalves within one chip enabling programmable injection of aqueous sample plugs, and nanoliter volumes transferred to a second microtrap array chip in which the plugs are actively discretized into picoliter droplets within a static array of membrane displacement actuators. The system employs two different multiplexer designs that reduce the number of input signals required for both sample injection and discretization. This versatile droplet-based technology offers flexible sample workflows and functionalities for the formation and manipulation of heterogeneous picoliter droplets, with particular utility for applications in biochemical synthesis and cell-based assays requiring flexible and programmable operation of parallel and multistep droplet processes. The platform is used here for the selective encapsulation of differentially labeled cells within a discrete droplet array." @default.
- W3004428305 created "2020-02-14" @default.
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- W3004428305 date "2020-01-01" @default.
- W3004428305 modified "2023-10-14" @default.
- W3004428305 title "A programmable microfluidic platform for multisample injection, discretization, and droplet manipulation" @default.
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- W3004428305 doi "https://doi.org/10.1063/1.5143434" @default.
- W3004428305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7002170" @default.
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