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- W3004443958 endingPage "1170" @default.
- W3004443958 startingPage "1170" @default.
- W3004443958 abstract "Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration. In animal models of Parkinson’s disease (PD), BDNF enhances the survival of dopaminergic neurons, improves dopaminergic neurotransmission and motor performance. Pharmacological therapies of PD are symptom-targeting, and their effectiveness decreases with the progression of the disease; therefore, new therapeutical approaches are needed. Since, in both PD patients and animal PD models, decreased level of BDNF was found in the nigrostriatal pathway, it has been hypothesized that BDNF may serve as a therapeutic agent. Direct delivery of exogenous BDNF into the patient’s brain did not relieve the symptoms of disease, nor did attempts to enhance BDNF expression with gene therapy. Physical training was neuroprotective in animal models of PD. This effect is mediated, at least partly, by BDNF. Animal studies revealed that physical activity increases BDNF and tropomyosin receptor kinase B (TrkB) expression, leading to inhibition of neurodegeneration through induction of transcription factors and expression of genes related to neuronal proliferation, survival, and inflammatory response. This review focuses on the evidence that increasing BDNF level due to gene modulation or physical exercise has a neuroprotective effect and could be considered as adjunctive therapy in PD." @default.
- W3004443958 created "2020-02-14" @default.
- W3004443958 creator A5006663728 @default.
- W3004443958 creator A5017635129 @default.
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- W3004443958 creator A5056235854 @default.
- W3004443958 creator A5089034937 @default.
- W3004443958 creator A5090724881 @default.
- W3004443958 date "2020-02-10" @default.
- W3004443958 modified "2023-10-11" @default.
- W3004443958 title "BDNF as a Promising Therapeutic Agent in Parkinson’s Disease" @default.
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