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- W3004447706 abstract "Angelicase Pubescentis Radix (APR) has been used in the practices of traditional Chinese medicine (TCM) with anti-rheumatoid arthritis (RA) effects called “wind-dampness-dispelling and cold dispersing”. In TCM prescriptions and patient medicines, APR has been widely adopted against RA. Till now, the anti-rheumatoid mechanisms are still obscure. In this study, bioactive compounds and targeted proteins based on experiment evidences were collected. Then, bioinformatics analysis towards RA was deployed. As a result, five RA associated biological processes were enriched with proteins targeted/regulated by APR e.g. ossification, osteoclast differentiation, positive regulation of lymph activation and regulation of T and B cell. The result can also be validated with bioinformatics tools and RA microarray data. In short, the anti-RA effect of APR recognized in TCM may associated with regulations on bone formation and inflammations." @default.
- W3004447706 created "2020-02-14" @default.
- W3004447706 creator A5013506158 @default.
- W3004447706 creator A5060861133 @default.
- W3004447706 date "2019-11-01" @default.
- W3004447706 modified "2023-09-24" @default.
- W3004447706 title "Anti-rheumatoid Arthritis Mechanisms of Angelicae Pubescentis Radix" @default.
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- W3004447706 doi "https://doi.org/10.1109/bibm47256.2019.8982935" @default.
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