FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004460824> ?p ?o ?g. }

• W3004460824 endingPage "3039" @default.
• W3004460824 startingPage "3034" @default.
• W3004460824 abstract "The antisense oligonucleotide Nusinersen has been recently licensed to treat spinal muscular atrophy (SMA). Since SMA type 3 is characterized by variable phenotype and milder progression, biomarkers of early treatment response are urgently needed. We investigated the cerebrospinal fluid (CSF) concentration of neurofilaments in SMA type 3 patients treated with Nusinersen as a potential biomarker of treatment efficacy. The concentration of phosphorylated neurofilaments heavy chain (pNfH) and light chain (NfL) in the CSF of SMA type 3 patients was evaluated before and after six months since the first Nusinersen administration, performed with commercially available enzyme-linked immunosorbent assay (ELISA) kits. Clinical evaluation of SMA patients was performed with standardized motor function scales. Baseline neurofilament levels in patients were comparable to controls, but significantly decreased after six months of treatment, while motor functions were only marginally ameliorated. No significant correlation was observed between the change in motor functions and that of neurofilaments over time. The reduction of neurofilament levels suggests a possible early biochemical effect of treatment on axonal degeneration, which may precede changes in motor performance. Our study mandates further investigations to assess neurofilaments as a marker of treatment response." @default.
• W3004460824 created "2020-02-14" @default.
• W3004460824 creator A5010611941 @default.
• W3004460824 creator A5020933929 @default.
• W3004460824 creator A5025891628 @default.
• W3004460824 creator A5032993233 @default.
• W3004460824 creator A5036214061 @default.
• W3004460824 creator A5038271133 @default.
• W3004460824 creator A5046111823 @default.
• W3004460824 creator A5046564023 @default.
• W3004460824 creator A5050312970 @default.
• W3004460824 creator A5053068628 @default.
• W3004460824 creator A5054695204 @default.
• W3004460824 creator A5056047513 @default.
• W3004460824 creator A5056591903 @default.
• W3004460824 creator A5060263136 @default.
• W3004460824 creator A5062637279 @default.
• W3004460824 creator A5066052658 @default.
• W3004460824 creator A5066388686 @default.
• W3004460824 creator A5067893944 @default.
• W3004460824 creator A5076321492 @default.
• W3004460824 creator A5080577078 @default.
• W3004460824 creator A5088712481 @default.
• W3004460824 date "2020-02-07" @default.
• W3004460824 modified "2023-10-15" @default.
• W3004460824 title "Nusinersen treatment and cerebrospinal fluid neurofilaments: An explorative study on Spinal Muscular Atrophy type 3 patients" @default.
• W3004460824 cites W1925547792 @default.
• W3004460824 cites W2039516764 @default.
• W3004460824 cites W2058262490 @default.
• W3004460824 cites W2119820612 @default.
• W3004460824 cites W2143197369 @default.
• W3004460824 cites W2342233016 @default.
• W3004460824 cites W2765483614 @default.
• W3004460824 cites W2771354240 @default.
• W3004460824 cites W2783169765 @default.
• W3004460824 cites W2889214184 @default.
• W3004460824 cites W2889223700 @default.
• W3004460824 cites W2909422691 @default.
• W3004460824 cites W2939958603 @default.
• W3004460824 cites W2942374408 @default.
• W3004460824 cites W2943910290 @default.
• W3004460824 cites W2945865866 @default.
• W3004460824 cites W2958891751 @default.
• W3004460824 doi "https://doi.org/10.1111/jcmm.14939" @default.
• W3004460824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7077557" @default.
• W3004460824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32032473" @default.
• W3004460824 hasPublicationYear "2020" @default.
• W3004460824 type Work @default.
• W3004460824 sameAs 3004460824 @default.
• W3004460824 citedByCount "39" @default.
• W3004460824 countsByYear W30044608242020 @default.
• W3004460824 countsByYear W30044608242021 @default.
• W3004460824 countsByYear W30044608242022 @default.
• W3004460824 countsByYear W30044608242023 @default.
• W3004460824 crossrefType "journal-article" @default.
• W3004460824 hasAuthorship W3004460824A5010611941 @default.
• W3004460824 hasAuthorship W3004460824A5020933929 @default.
• W3004460824 hasAuthorship W3004460824A5025891628 @default.
• W3004460824 hasAuthorship W3004460824A5032993233 @default.
• W3004460824 hasAuthorship W3004460824A5036214061 @default.
• W3004460824 hasAuthorship W3004460824A5038271133 @default.
• W3004460824 hasAuthorship W3004460824A5046111823 @default.
• W3004460824 hasAuthorship W3004460824A5046564023 @default.
• W3004460824 hasAuthorship W3004460824A5050312970 @default.
• W3004460824 hasAuthorship W3004460824A5053068628 @default.
• W3004460824 hasAuthorship W3004460824A5054695204 @default.
• W3004460824 hasAuthorship W3004460824A5056047513 @default.
• W3004460824 hasAuthorship W3004460824A5056591903 @default.
• W3004460824 hasAuthorship W3004460824A5060263136 @default.
• W3004460824 hasAuthorship W3004460824A5062637279 @default.
• W3004460824 hasAuthorship W3004460824A5066052658 @default.
• W3004460824 hasAuthorship W3004460824A5066388686 @default.
• W3004460824 hasAuthorship W3004460824A5067893944 @default.
• W3004460824 hasAuthorship W3004460824A5076321492 @default.
• W3004460824 hasAuthorship W3004460824A5080577078 @default.
• W3004460824 hasAuthorship W3004460824A5088712481 @default.
• W3004460824 hasBestOaLocation W30044608241 @default.
• W3004460824 hasConcept C105702510 @default.
• W3004460824 hasConcept C142724271 @default.
• W3004460824 hasConcept C157207234 @default.
• W3004460824 hasConcept C204232928 @default.
• W3004460824 hasConcept C2778558090 @default.
• W3004460824 hasConcept C2779134260 @default.
• W3004460824 hasConcept C2779651940 @default.
• W3004460824 hasConcept C2781172350 @default.
• W3004460824 hasConcept C71924100 @default.
• W3004460824 hasConceptScore W3004460824C105702510 @default.
• W3004460824 hasConceptScore W3004460824C142724271 @default.
• W3004460824 hasConceptScore W3004460824C157207234 @default.
• W3004460824 hasConceptScore W3004460824C204232928 @default.
• W3004460824 hasConceptScore W3004460824C2778558090 @default.
• W3004460824 hasConceptScore W3004460824C2779134260 @default.
• W3004460824 hasConceptScore W3004460824C2779651940 @default.
• W3004460824 hasConceptScore W3004460824C2781172350 @default.
• W3004460824 hasConceptScore W3004460824C71924100 @default.
• W3004460824 hasFunder F4320321781 @default.
• W3004460824 hasFunder F4320326078 @default.
• W3004460824 hasIssue "5" @default.

• next