Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004485776> ?p ?o ?g. }
- W3004485776 endingPage "127" @default.
- W3004485776 startingPage "99" @default.
- W3004485776 abstract "The Rho-ROCK signaling network has a range of specialized functions of key biological importance, including control of essential developmental processes such as morphogenesis and physiological processes including homeostasis, immunity, and wound healing. Deregulation of Rho-ROCK signaling actively contributes to multiple pathological conditions, and plays a major role in cancer development and progression. This dynamic network is critical in modulating the intricate communication between tumor cells, surrounding diverse stromal cells and the matrix, shaping the ever-changing microenvironment of aggressive tumors. In this chapter, we overview the complex regulation of the Rho-ROCK signaling axis, its role in health and disease, and analyze progress made with key approaches targeting the Rho-ROCK pathway for therapeutic benefit. Finally, we conclude by outlining likely future trends and key questions in the field of Rho-ROCK research, in particular surrounding Rho-ROCK signaling within the tumor microenvironment." @default.
- W3004485776 created "2020-02-14" @default.
- W3004485776 creator A5058096024 @default.
- W3004485776 creator A5073106472 @default.
- W3004485776 creator A5087181243 @default.
- W3004485776 date "2020-01-01" @default.
- W3004485776 modified "2023-10-13" @default.
- W3004485776 title "Rho-ROCK Signaling in Normal Physiology and as a Key Player in Shaping the Tumor Microenvironment" @default.
- W3004485776 cites W1500219445 @default.
- W3004485776 cites W1548960004 @default.
- W3004485776 cites W1576237248 @default.
- W3004485776 cites W1593627702 @default.
- W3004485776 cites W1601681275 @default.
- W3004485776 cites W1780009378 @default.
- W3004485776 cites W1848923750 @default.
- W3004485776 cites W1944127753 @default.
- W3004485776 cites W1965619419 @default.
- W3004485776 cites W1966228205 @default.
- W3004485776 cites W1969564302 @default.
- W3004485776 cites W1971386805 @default.
- W3004485776 cites W1971922932 @default.
- W3004485776 cites W1974941580 @default.
- W3004485776 cites W1975837861 @default.
- W3004485776 cites W1977381126 @default.
- W3004485776 cites W1978729515 @default.
- W3004485776 cites W1983081586 @default.
- W3004485776 cites W1983086891 @default.
- W3004485776 cites W1983749425 @default.
- W3004485776 cites W1984727579 @default.
- W3004485776 cites W1985383424 @default.
- W3004485776 cites W1987162518 @default.
- W3004485776 cites W1987313243 @default.
- W3004485776 cites W1987624648 @default.
- W3004485776 cites W1995306997 @default.
- W3004485776 cites W1996879480 @default.
- W3004485776 cites W1996912024 @default.
- W3004485776 cites W1997623655 @default.
- W3004485776 cites W1999133016 @default.
- W3004485776 cites W2001058227 @default.
- W3004485776 cites W2002122463 @default.
- W3004485776 cites W2002194537 @default.
- W3004485776 cites W2002373478 @default.
- W3004485776 cites W2005763654 @default.
- W3004485776 cites W2008407092 @default.
- W3004485776 cites W2009544604 @default.
- W3004485776 cites W2009549317 @default.
- W3004485776 cites W2010735936 @default.
- W3004485776 cites W2011177881 @default.
- W3004485776 cites W2011379117 @default.
- W3004485776 cites W2013660816 @default.
- W3004485776 cites W2014282546 @default.
- W3004485776 cites W2015719127 @default.
- W3004485776 cites W2015985931 @default.
- W3004485776 cites W2016193552 @default.
- W3004485776 cites W2017890252 @default.
- W3004485776 cites W2018327197 @default.
- W3004485776 cites W2019697704 @default.
- W3004485776 cites W2020320400 @default.
- W3004485776 cites W2020476087 @default.
- W3004485776 cites W2020575974 @default.
- W3004485776 cites W2022495797 @default.
- W3004485776 cites W2023118601 @default.
- W3004485776 cites W2023780438 @default.
- W3004485776 cites W2027108471 @default.
- W3004485776 cites W2027683842 @default.
- W3004485776 cites W2031089985 @default.
- W3004485776 cites W2031409539 @default.
- W3004485776 cites W2031450490 @default.
- W3004485776 cites W2032041393 @default.
- W3004485776 cites W2033555492 @default.
- W3004485776 cites W2033998652 @default.
- W3004485776 cites W2035000040 @default.
- W3004485776 cites W2038569449 @default.
- W3004485776 cites W2039898135 @default.
- W3004485776 cites W2042111453 @default.
- W3004485776 cites W2045173243 @default.
- W3004485776 cites W2045234862 @default.
- W3004485776 cites W2047580046 @default.
- W3004485776 cites W2048674030 @default.
- W3004485776 cites W2055395938 @default.
- W3004485776 cites W2056326894 @default.
- W3004485776 cites W2056423987 @default.
- W3004485776 cites W2056850877 @default.
- W3004485776 cites W2057439428 @default.
- W3004485776 cites W2061340775 @default.
- W3004485776 cites W2061600983 @default.
- W3004485776 cites W2061767895 @default.
- W3004485776 cites W2062809449 @default.
- W3004485776 cites W2065136899 @default.
- W3004485776 cites W2065849940 @default.
- W3004485776 cites W2066135299 @default.
- W3004485776 cites W2066211195 @default.
- W3004485776 cites W2066482548 @default.
- W3004485776 cites W2066700256 @default.
- W3004485776 cites W2068413602 @default.
- W3004485776 cites W2069271377 @default.
- W3004485776 cites W2069738597 @default.
- W3004485776 cites W2070657240 @default.