FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004540206> ?p ?o ?g. }

• W3004540206 endingPage "224" @default.
• W3004540206 startingPage "224" @default.
• W3004540206 abstract "Since 2014, highly pathogenic avian influenza (HPAI) H5N6 viruses have circulated in waterfowls and caused human infections in China, posing significant threats to the poultry industry and the public health. However, the genetics, pathogenicity and innate immune response of H5N6 HPAIVs in geese remain largely unknown. In this study, we analyzed the genetic characteristic of the two H5N6 viruses (GS38 and DK09) isolated from apparently healthy domestic goose and duck in live poultry markets (LPMs) of Southern China in 2016. Phylogenetic analysis showed that the HA genes of the two H5N6 viruses belonged to clade 2.3.4.4 and were clustered into the MIX-like group. The MIX-like group viruses have circulated in regions such as China, Japan, Korea, and Vietnam. The NA genes of the two H5N6 viruses were classified into the Eurasian sublineage. The internal genes including PB2, PB1, PA, NP, M, and NS of the two H5N6 viruses derived from the MIX-like. Therefore, our results suggested that the two H5N6 viruses were reassortants of the H5N1 and H6N6 viruses and likely derived from the same ancestor. Additionally, we evaluated the pathogenicity and transmission of the two H5N6 viruses in domestic geese. Results showed that both the two viruses caused serious clinical symptoms in all inoculated geese and led to high mortality in these birds. Both the two viruses were transmitted efficiently to contact geese and caused lethal infection in these birds. Furthermore, we found that mRNA of pattern recognition receptors (PRRs), interferons (IFNs), and stimulated genes (ISGs) exhibited different levels of activation in the lungs and spleens of the two H5N6 viruses-inoculated geese though did not protect these birds from H5N6 HPAIVs infection. Our results suggested that the clade 2.3.4.4 waterfowl-origin H5N6 HPAIVs isolated from LPMs of Southern China could cause high mortality in geese and innate immune-related genes were involved in the geese innate immune response to H5N6 HPAIVs infection. Therefore, we should pay more attention to the evolution, pathogenic variations of these viruses and enhance virological surveillance of clade 2.3.4.4 H5N6 HPAIVs in waterfowls in China." @default.
• W3004540206 created "2020-02-14" @default.
• W3004540206 creator A5008686070 @default.
• W3004540206 creator A5035282947 @default.
• W3004540206 creator A5036752754 @default.
• W3004540206 creator A5036769734 @default.
• W3004540206 creator A5040035399 @default.
• W3004540206 creator A5043445282 @default.
• W3004540206 creator A5073823650 @default.
• W3004540206 creator A5080734846 @default.
• W3004540206 creator A5082899487 @default.
• W3004540206 date "2020-02-07" @default.
• W3004540206 modified "2023-10-17" @default.
• W3004540206 title "Host Innate Immune Response of Geese Infected with Clade 2.3.4.4 H5N6 Highly Pathogenic Avian Influenza Viruses" @default.
• W3004540206 cites W1967139772 @default.
• W3004540206 cites W1967415529 @default.
• W3004540206 cites W1979838502 @default.
• W3004540206 cites W1980290172 @default.
• W3004540206 cites W1988851601 @default.
• W3004540206 cites W1989524330 @default.
• W3004540206 cites W1999320428 @default.
• W3004540206 cites W2003474402 @default.
• W3004540206 cites W2006079378 @default.
• W3004540206 cites W2010621687 @default.
• W3004540206 cites W2012627412 @default.
• W3004540206 cites W2024970913 @default.
• W3004540206 cites W2030895743 @default.
• W3004540206 cites W2031908280 @default.
• W3004540206 cites W2037923342 @default.
• W3004540206 cites W2047505752 @default.
• W3004540206 cites W2050589013 @default.
• W3004540206 cites W2052330831 @default.
• W3004540206 cites W2055111450 @default.
• W3004540206 cites W2069831575 @default.
• W3004540206 cites W2084667551 @default.
• W3004540206 cites W2092903823 @default.
• W3004540206 cites W2093983981 @default.
• W3004540206 cites W2097196885 @default.
• W3004540206 cites W2102838269 @default.
• W3004540206 cites W2104373123 @default.
• W3004540206 cites W2109593713 @default.
• W3004540206 cites W2112687224 @default.
• W3004540206 cites W2124208765 @default.
• W3004540206 cites W2130597972 @default.
• W3004540206 cites W2135094423 @default.
• W3004540206 cites W2136494098 @default.
• W3004540206 cites W2140626089 @default.
• W3004540206 cites W2148681541 @default.
• W3004540206 cites W2150403537 @default.
• W3004540206 cites W2153672841 @default.
• W3004540206 cites W2155962399 @default.
• W3004540206 cites W2159734253 @default.
• W3004540206 cites W2165690966 @default.
• W3004540206 cites W2166455345 @default.
• W3004540206 cites W2180958546 @default.
• W3004540206 cites W2193331226 @default.
• W3004540206 cites W2268009881 @default.
• W3004540206 cites W2306284666 @default.
• W3004540206 cites W2336874512 @default.
• W3004540206 cites W2402159559 @default.
• W3004540206 cites W2557499142 @default.
• W3004540206 cites W2718202718 @default.
• W3004540206 cites W2743152543 @default.
• W3004540206 cites W2748300016 @default.
• W3004540206 cites W2766125601 @default.
• W3004540206 cites W2796950595 @default.
• W3004540206 cites W2809673692 @default.
• W3004540206 cites W2893068856 @default.
• W3004540206 cites W2961415854 @default.
• W3004540206 cites W2963024554 @default.
• W3004540206 cites W2963710877 @default.
• W3004540206 cites W4248433360 @default.
• W3004540206 doi "https://doi.org/10.3390/microorganisms8020224" @default.
• W3004540206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7074872" @default.
• W3004540206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32046051" @default.
• W3004540206 hasPublicationYear "2020" @default.
• W3004540206 type Work @default.
• W3004540206 sameAs 3004540206 @default.
• W3004540206 citedByCount "2" @default.
• W3004540206 countsByYear W30045402062021 @default.
• W3004540206 countsByYear W30045402062023 @default.
• W3004540206 crossrefType "journal-article" @default.
• W3004540206 hasAuthorship W3004540206A5008686070 @default.
• W3004540206 hasAuthorship W3004540206A5035282947 @default.
• W3004540206 hasAuthorship W3004540206A5036752754 @default.
• W3004540206 hasAuthorship W3004540206A5036769734 @default.
• W3004540206 hasAuthorship W3004540206A5040035399 @default.
• W3004540206 hasAuthorship W3004540206A5043445282 @default.
• W3004540206 hasAuthorship W3004540206A5073823650 @default.
• W3004540206 hasAuthorship W3004540206A5080734846 @default.
• W3004540206 hasAuthorship W3004540206A5082899487 @default.
• W3004540206 hasBestOaLocation W30045402061 @default.
• W3004540206 hasConcept C104317684 @default.
• W3004540206 hasConcept C126831891 @default.
• W3004540206 hasConcept C136449434 @default.
• W3004540206 hasConcept C142724271 @default.
• W3004540206 hasConcept C159047783 @default.
• W3004540206 hasConcept C16154277 @default.

• next