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- W3004559006 abstract "ABSTRACT Dendritic hotspots have been shown to play a determining role as local activity foci during sensory information coding and memory formation in cortical neurons in vivo . Here we aim to reveal the characteristics of co-activating more dendritic hotspots themselves within a dynamic time window. Using electrical stimulation and patterned two-photon uncaging for the coincident activation of two neighboring dendritic hotspots in rat hippocampal CA1 interneurons, the evoked local dendritic Ca 2+ and the associated excitatory postsynaptic potentials (EPSPs) summed supralinearly. Between active hotspots, supralinearity was present in a relatively broad temporal (∼10 ms) and spatial (∼30 µm) window, mediated by NMDA receptors. Though at larger inter-hotspot distances (>30 µm) supralinear summation of EPSPs was replaced by sublinear integration, the summation of dendritic Ca 2+ responses remained supralinear. The inter-hotspot integration represents a novel signal integration state, extending the interaction distance between dendritic inputs, and allowing long-range coincidence detection." @default.
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- W3004559006 date "2020-02-07" @default.
- W3004559006 modified "2023-10-12" @default.
- W3004559006 title "Non-linear Computation Between Neighboring Dendritic Hotspots in Rat CA1 Hippocampal Interneurons" @default.
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- W3004559006 doi "https://doi.org/10.1101/2020.02.06.936989" @default.
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