FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004565182> ?p ?o ?g. }

• W3004565182 abstract "Abstract A link between periodontitis and atherothrombosis has been highlighted. The aim of this study was to determine the influence of Porphyromonas gingivalis on endothelial microvesicles (EMV Pg ) shedding and their contribution to endothelial inflammation. Endothelial cells (EC) were infected with P. gingivalis (MOI = 100) for 24 h. EMV Pg were isolated and their concentration was evaluated by prothrombinase assay. EMV Pg were significantly increased in comparison with EMV Ctrl shedded by unstimulated cells. While EMV Ctrl from untreated EC had no effect, whereas, the proportion of apoptotic EC was increased by 30 nM EMV Pg and viability was decreased down to 25%, a value elicited by P. gingivalis alone. Moreover, high concentration of EMV Pg (30 nM) induced a pro-inflammatory and pro-oxidative cell response including up-regulation of TNF-α, IL-6 and IL-8 as well as an altered expression of iNOS and eNOS at both mRNA and protein level. An increase of VCAM-1 and ICAM-1 mRNA expression (4.5 folds and 3 folds respectively ( p < 0.05 vs untreated) was also observed after EMV Pg (30 nM) stimulation whereas P. gingivalis infection was less effective, suggesting a specific triggering by EMV Pg . Kinasome analysis demonstrated the specific effect induced by EMV Pg on main pro-inflammatory pathways including JNK/AKT and STAT. EMV Pg are effective pro-inflammatory effectors that may have detrimental effect on vascular homeostasis and should be considered as potential autocrine and paracrine effectors involved in the link between periodontitis and atherothrombosis." @default.
• W3004565182 created "2020-02-14" @default.
• W3004565182 creator A5023416331 @default.
• W3004565182 creator A5048057040 @default.
• W3004565182 creator A5055451729 @default.
• W3004565182 creator A5062720421 @default.
• W3004565182 creator A5068713469 @default.
• W3004565182 creator A5069652712 @default.
• W3004565182 creator A5074955861 @default.
• W3004565182 creator A5081011015 @default.
• W3004565182 date "2020-02-04" @default.
• W3004565182 modified "2023-10-16" @default.
• W3004565182 title "Porphyromonas gingivalis triggers the shedding of inflammatory endothelial microvesicles that act as autocrine effectors of endothelial dysfunction" @default.
• W3004565182 cites W1555041989 @default.
• W3004565182 cites W1571823809 @default.
• W3004565182 cites W1910268468 @default.
• W3004565182 cites W1965056341 @default.
• W3004565182 cites W1965561992 @default.
• W3004565182 cites W1966294883 @default.
• W3004565182 cites W1967303282 @default.
• W3004565182 cites W1974041214 @default.
• W3004565182 cites W1979959112 @default.
• W3004565182 cites W1984946407 @default.
• W3004565182 cites W1985225188 @default.
• W3004565182 cites W1985817408 @default.
• W3004565182 cites W1987431872 @default.
• W3004565182 cites W1987891420 @default.
• W3004565182 cites W1988533632 @default.
• W3004565182 cites W1989081076 @default.
• W3004565182 cites W1991021491 @default.
• W3004565182 cites W1991341713 @default.
• W3004565182 cites W1999834156 @default.
• W3004565182 cites W2000429688 @default.
• W3004565182 cites W2004634206 @default.
• W3004565182 cites W2010581139 @default.
• W3004565182 cites W2010983045 @default.
• W3004565182 cites W2013325992 @default.
• W3004565182 cites W2021838232 @default.
• W3004565182 cites W2034035669 @default.
• W3004565182 cites W2041645239 @default.
• W3004565182 cites W2075052436 @default.
• W3004565182 cites W2078890177 @default.
• W3004565182 cites W2080350120 @default.
• W3004565182 cites W2090628166 @default.
• W3004565182 cites W2098494194 @default.
• W3004565182 cites W2099920676 @default.
• W3004565182 cites W2109704767 @default.
• W3004565182 cites W2110672879 @default.
• W3004565182 cites W2121451087 @default.
• W3004565182 cites W2122187912 @default.
• W3004565182 cites W2124366091 @default.
• W3004565182 cites W2142643588 @default.
• W3004565182 cites W2142773205 @default.
• W3004565182 cites W2147012991 @default.
• W3004565182 cites W2147331510 @default.
• W3004565182 cites W2148912798 @default.
• W3004565182 cites W2150795824 @default.
• W3004565182 cites W2151830751 @default.
• W3004565182 cites W2151948534 @default.
• W3004565182 cites W2154339285 @default.
• W3004565182 cites W2160909868 @default.
• W3004565182 cites W2171942854 @default.
• W3004565182 cites W2209996917 @default.
• W3004565182 cites W2344215583 @default.
• W3004565182 cites W2552707934 @default.
• W3004565182 cites W2571494361 @default.
• W3004565182 cites W2579866418 @default.
• W3004565182 cites W2587563462 @default.
• W3004565182 cites W2606541213 @default.
• W3004565182 cites W2607189590 @default.
• W3004565182 cites W2620594759 @default.
• W3004565182 cites W2734620335 @default.
• W3004565182 cites W2756339776 @default.
• W3004565182 cites W2769992617 @default.
• W3004565182 cites W2770189780 @default.
• W3004565182 cites W2773107217 @default.
• W3004565182 cites W2775359073 @default.
• W3004565182 cites W2805501226 @default.
• W3004565182 cites W2808801451 @default.
• W3004565182 cites W2883422321 @default.
• W3004565182 cites W2885245088 @default.
• W3004565182 cites W2898257452 @default.
• W3004565182 cites W2900446046 @default.
• W3004565182 cites W2914237180 @default.
• W3004565182 cites W2945080417 @default.
• W3004565182 cites W2946521848 @default.
• W3004565182 cites W4211095696 @default.
• W3004565182 cites W824570847 @default.
• W3004565182 doi "https://doi.org/10.1038/s41598-020-58374-z" @default.
• W3004565182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7000667" @default.
• W3004565182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32019950" @default.
• W3004565182 hasPublicationYear "2020" @default.
• W3004565182 type Work @default.
• W3004565182 sameAs 3004565182 @default.
• W3004565182 citedByCount "18" @default.
• W3004565182 countsByYear W30045651822020 @default.
• W3004565182 countsByYear W30045651822021 @default.
• W3004565182 countsByYear W30045651822022 @default.
• W3004565182 countsByYear W30045651822023 @default.
• W3004565182 crossrefType "journal-article" @default.

• next