Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004583890> ?p ?o ?g. }
- W3004583890 endingPage "1002" @default.
- W3004583890 startingPage "990" @default.
- W3004583890 abstract "Chronic liver disease and primary liver cancer are a massive global problem, with a future increase in incidences predicted. The most prevalent form of primary liver cancer, hepatocellular carcinoma, occurs after years of chronic liver disease. Mutations in the genome are a causative and defining feature of all cancers. Chronic liver disease, mostly at the cirrhotic stage, causes the accumulation of progressive mutations which can drive cancer development. Within the liver, a Darwinian process selects out dominant clones with selected driver mutations but also leaves a trail of passenger mutations which can be used to track the evolution of a tumour. Understanding what causes specific mutations and how they combine with one another to form cancer is a question at the heart of understanding, preventing and tackling liver cancer. Herein, we review the landscape of gene mutations in cirrhosis, especially those paving the way toward hepatocellular carcinoma development, that have been characterised by recent studies capitalising on technological advances in genomic sequencing. With these insights, we are beginning to understand how cancers form in the liver, particularly on the background of chronic liver disease. This knowledge may soon lead to breakthroughs in the way we detect, diagnose and treat this devastating disease." @default.
- W3004583890 created "2020-02-14" @default.
- W3004583890 creator A5034566517 @default.
- W3004583890 creator A5038343376 @default.
- W3004583890 creator A5044809916 @default.
- W3004583890 date "2020-05-01" @default.
- W3004583890 modified "2023-10-14" @default.
- W3004583890 title "The landscape of gene mutations in cirrhosis and hepatocellular carcinoma" @default.
- W3004583890 cites W1585869774 @default.
- W3004583890 cites W1587107897 @default.
- W3004583890 cites W1760327871 @default.
- W3004583890 cites W1821381892 @default.
- W3004583890 cites W1956871134 @default.
- W3004583890 cites W1965151932 @default.
- W3004583890 cites W1966549856 @default.
- W3004583890 cites W1967304777 @default.
- W3004583890 cites W1968856828 @default.
- W3004583890 cites W1971248187 @default.
- W3004583890 cites W1973027060 @default.
- W3004583890 cites W1974970634 @default.
- W3004583890 cites W1981054850 @default.
- W3004583890 cites W1982318323 @default.
- W3004583890 cites W1982959726 @default.
- W3004583890 cites W1983132744 @default.
- W3004583890 cites W1985794749 @default.
- W3004583890 cites W1989438630 @default.
- W3004583890 cites W1990563353 @default.
- W3004583890 cites W1990765314 @default.
- W3004583890 cites W1997769423 @default.
- W3004583890 cites W2008079377 @default.
- W3004583890 cites W2009671859 @default.
- W3004583890 cites W2017511982 @default.
- W3004583890 cites W2018851752 @default.
- W3004583890 cites W2022425899 @default.
- W3004583890 cites W2025966264 @default.
- W3004583890 cites W2028593002 @default.
- W3004583890 cites W2031709894 @default.
- W3004583890 cites W2035794058 @default.
- W3004583890 cites W2040358727 @default.
- W3004583890 cites W2040606106 @default.
- W3004583890 cites W2041390659 @default.
- W3004583890 cites W2042956118 @default.
- W3004583890 cites W2044136402 @default.
- W3004583890 cites W2046216416 @default.
- W3004583890 cites W2048177238 @default.
- W3004583890 cites W2051001918 @default.
- W3004583890 cites W2051876644 @default.
- W3004583890 cites W2059300459 @default.
- W3004583890 cites W2060043441 @default.
- W3004583890 cites W2067224679 @default.
- W3004583890 cites W2068127752 @default.
- W3004583890 cites W2069083348 @default.
- W3004583890 cites W2071180264 @default.
- W3004583890 cites W2075793367 @default.
- W3004583890 cites W2076038974 @default.
- W3004583890 cites W2085075365 @default.
- W3004583890 cites W2085114559 @default.
- W3004583890 cites W2085652695 @default.
- W3004583890 cites W2087449142 @default.
- W3004583890 cites W2097260622 @default.
- W3004583890 cites W2102577928 @default.
- W3004583890 cites W2108638605 @default.
- W3004583890 cites W2116005044 @default.
- W3004583890 cites W2117785761 @default.
- W3004583890 cites W2119657975 @default.
- W3004583890 cites W2129136620 @default.
- W3004583890 cites W2133348533 @default.
- W3004583890 cites W2146948091 @default.
- W3004583890 cites W2152061559 @default.
- W3004583890 cites W2158378236 @default.
- W3004583890 cites W2158495358 @default.
- W3004583890 cites W2204695746 @default.
- W3004583890 cites W2264459792 @default.
- W3004583890 cites W2277004004 @default.
- W3004583890 cites W2332282497 @default.
- W3004583890 cites W2341442578 @default.
- W3004583890 cites W2394817547 @default.
- W3004583890 cites W2468596757 @default.
- W3004583890 cites W2524881570 @default.
- W3004583890 cites W2559991443 @default.
- W3004583890 cites W2563604790 @default.
- W3004583890 cites W2569119721 @default.
- W3004583890 cites W2581107742 @default.
- W3004583890 cites W2611387862 @default.
- W3004583890 cites W2613362156 @default.
- W3004583890 cites W2625559053 @default.
- W3004583890 cites W2625856057 @default.
- W3004583890 cites W2626033245 @default.
- W3004583890 cites W2734880494 @default.
- W3004583890 cites W2756331708 @default.
- W3004583890 cites W2763620027 @default.
- W3004583890 cites W2766220272 @default.
- W3004583890 cites W2771057425 @default.
- W3004583890 cites W2784418525 @default.
- W3004583890 cites W2786099441 @default.
- W3004583890 cites W2790198401 @default.
- W3004583890 cites W2792034207 @default.
- W3004583890 cites W2793543636 @default.