Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004607922> ?p ?o ?g. }
- W3004607922 endingPage "3703" @default.
- W3004607922 startingPage "3693" @default.
- W3004607922 abstract "Glioblastoma is the most aggressive brain malignancy, for which immunotherapy has failed to prolong survival. Glioblastoma-associated immune infiltrates are dominated by tumor-associated macrophages and microglia (TAMs), which are key mediators of immune suppression and resistance to immunotherapy. We and others demonstrated aberrant expression of glycans in different cancer types. These tumor-associated glycans trigger inhibitory signaling in TAMs through glycan-binding receptors. We investigated the glioblastoma glycocalyx as a tumor-intrinsic immune suppressor. We detected increased expression of both tumor-associated truncated O-linked glycans and their receptor, macrophage galactose-type lectin (MGL), on CD163 + TAMs in glioblastoma patient-derived tumor tissues. In an immunocompetent orthotopic glioma mouse model overexpressing truncated O-linked glycans (MGL ligands), high-dimensional mass cytometry revealed a wide heterogeneity of infiltrating myeloid cells with increased infiltration of PD-L1 + TAMs as well as distant alterations in the bone marrow (BM). Our results demonstrate that glioblastomas exploit cell surface O-linked glycans for local and distant immune modulation." @default.
- W3004607922 created "2020-02-14" @default.
- W3004607922 creator A5003030389 @default.
- W3004607922 creator A5003337630 @default.
- W3004607922 creator A5009217310 @default.
- W3004607922 creator A5013242801 @default.
- W3004607922 creator A5021440888 @default.
- W3004607922 creator A5024226262 @default.
- W3004607922 creator A5026124235 @default.
- W3004607922 creator A5027398481 @default.
- W3004607922 creator A5028528916 @default.
- W3004607922 creator A5028891344 @default.
- W3004607922 creator A5031807229 @default.
- W3004607922 creator A5045424398 @default.
- W3004607922 creator A5050961926 @default.
- W3004607922 creator A5051927182 @default.
- W3004607922 creator A5053700204 @default.
- W3004607922 creator A5057103165 @default.
- W3004607922 creator A5063072287 @default.
- W3004607922 creator A5063693691 @default.
- W3004607922 creator A5063795536 @default.
- W3004607922 creator A5078783643 @default.
- W3004607922 date "2020-02-04" @default.
- W3004607922 modified "2023-10-09" @default.
- W3004607922 title "Glioblastomas exploit truncated O <i>-</i> linked glycans for local and distant immune modulation via the macrophage galactose-type lectin" @default.
- W3004607922 cites W11607516 @default.
- W3004607922 cites W1182461782 @default.
- W3004607922 cites W1544375765 @default.
- W3004607922 cites W1596721271 @default.
- W3004607922 cites W1629551726 @default.
- W3004607922 cites W1815157104 @default.
- W3004607922 cites W1964144818 @default.
- W3004607922 cites W1970170720 @default.
- W3004607922 cites W1971907885 @default.
- W3004607922 cites W1972305772 @default.
- W3004607922 cites W1977709885 @default.
- W3004607922 cites W1978873861 @default.
- W3004607922 cites W1980485314 @default.
- W3004607922 cites W1983180112 @default.
- W3004607922 cites W1990092860 @default.
- W3004607922 cites W1995611890 @default.
- W3004607922 cites W2007058937 @default.
- W3004607922 cites W2012106289 @default.
- W3004607922 cites W2015751584 @default.
- W3004607922 cites W2017698875 @default.
- W3004607922 cites W2024626836 @default.
- W3004607922 cites W2028695285 @default.
- W3004607922 cites W2030567730 @default.
- W3004607922 cites W2035738127 @default.
- W3004607922 cites W2038426170 @default.
- W3004607922 cites W2040773741 @default.
- W3004607922 cites W2053400250 @default.
- W3004607922 cites W2055331277 @default.
- W3004607922 cites W2059282001 @default.
- W3004607922 cites W2077312152 @default.
- W3004607922 cites W2079487111 @default.
- W3004607922 cites W2080198588 @default.
- W3004607922 cites W2085892104 @default.
- W3004607922 cites W2088717724 @default.
- W3004607922 cites W2096287682 @default.
- W3004607922 cites W2099195012 @default.
- W3004607922 cites W2099543897 @default.
- W3004607922 cites W2114490778 @default.
- W3004607922 cites W2121446189 @default.
- W3004607922 cites W2129374849 @default.
- W3004607922 cites W2134046076 @default.
- W3004607922 cites W2137548222 @default.
- W3004607922 cites W2141706559 @default.
- W3004607922 cites W2144801376 @default.
- W3004607922 cites W2151416708 @default.
- W3004607922 cites W2154539740 @default.
- W3004607922 cites W2164749173 @default.
- W3004607922 cites W2167582336 @default.
- W3004607922 cites W2169819811 @default.
- W3004607922 cites W2170150820 @default.
- W3004607922 cites W2220215167 @default.
- W3004607922 cites W2274336449 @default.
- W3004607922 cites W2290698646 @default.
- W3004607922 cites W2293496672 @default.
- W3004607922 cites W2299861382 @default.
- W3004607922 cites W2399474824 @default.
- W3004607922 cites W2464824038 @default.
- W3004607922 cites W2471500324 @default.
- W3004607922 cites W250971327 @default.
- W3004607922 cites W2528779404 @default.
- W3004607922 cites W2567424265 @default.
- W3004607922 cites W2583978691 @default.
- W3004607922 cites W2591531756 @default.
- W3004607922 cites W2594694689 @default.
- W3004607922 cites W2606294279 @default.
- W3004607922 cites W2734467035 @default.
- W3004607922 cites W2740447745 @default.
- W3004607922 cites W2768159696 @default.
- W3004607922 cites W2768365920 @default.
- W3004607922 cites W2787237920 @default.
- W3004607922 cites W2791954023 @default.
- W3004607922 cites W2796584001 @default.
- W3004607922 cites W2799394015 @default.