Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004613193> ?p ?o ?g. }
- W3004613193 abstract "Abstract The human X and Y chromosomes evolved from a pair of autosomes approximately 180 million years ago. Despite their shared evolutionary origin, extensive genetic decay has resulted in the human Y chromosome losing 97% of its ancestral genes while gene content and order remain highly conserved on the X chromosome. Five ‘stratification’ events, most likely inversions, reduced the Y chromosome’s ability to recombine with the X chromosome across the majority of its length and subjected its genes to the erosive forces associated with reduced recombination. The remaining functional genes are ubiquitously expressed, functionally coherent, dosage-sensitive genes, or have evolved male-specific functionality. It is unknown, however, whether functional specialization is a degenerative phenomenon unique to sex chromosomes, or if it conveys a potential selective advantage aside from sexual antagonism. We examined the evolution of mammalian orthologs to determine if the selective forces that led to the degeneration of the Y chromosome are unique in the genome. The results of our study suggest these forces are not exclusive to the Y chromosome, and chromosomal degeneration may have occurred throughout our evolutionary history. The reduction of recombination could additionally result in rapid fixation through isolation of specialized functions resulting in a cost-benefit relationship during times of intense selective pressure." @default.
- W3004613193 created "2020-02-14" @default.
- W3004613193 creator A5035594006 @default.
- W3004613193 creator A5047233734 @default.
- W3004613193 creator A5072779805 @default.
- W3004613193 date "2020-02-07" @default.
- W3004613193 modified "2023-09-26" @default.
- W3004613193 title "Extinction of chromosomes due to specialization is a universal occurrence" @default.
- W3004613193 cites W1488871786 @default.
- W3004613193 cites W1546156265 @default.
- W3004613193 cites W1673606065 @default.
- W3004613193 cites W1679571303 @default.
- W3004613193 cites W1891078220 @default.
- W3004613193 cites W1913751214 @default.
- W3004613193 cites W1934871552 @default.
- W3004613193 cites W1939885667 @default.
- W3004613193 cites W1964885249 @default.
- W3004613193 cites W1967470558 @default.
- W3004613193 cites W1972628065 @default.
- W3004613193 cites W1980135271 @default.
- W3004613193 cites W1981301360 @default.
- W3004613193 cites W1984083837 @default.
- W3004613193 cites W1984433655 @default.
- W3004613193 cites W1991663951 @default.
- W3004613193 cites W1993651315 @default.
- W3004613193 cites W1994927285 @default.
- W3004613193 cites W1995169648 @default.
- W3004613193 cites W1996025518 @default.
- W3004613193 cites W2006800383 @default.
- W3004613193 cites W2009031743 @default.
- W3004613193 cites W2010407417 @default.
- W3004613193 cites W2017205393 @default.
- W3004613193 cites W2018990052 @default.
- W3004613193 cites W2019350341 @default.
- W3004613193 cites W2019591778 @default.
- W3004613193 cites W2020613289 @default.
- W3004613193 cites W2021998028 @default.
- W3004613193 cites W2024754608 @default.
- W3004613193 cites W2026057878 @default.
- W3004613193 cites W2027318023 @default.
- W3004613193 cites W2027648691 @default.
- W3004613193 cites W2030191595 @default.
- W3004613193 cites W2032267743 @default.
- W3004613193 cites W2032311106 @default.
- W3004613193 cites W2032362270 @default.
- W3004613193 cites W2037392125 @default.
- W3004613193 cites W2038464976 @default.
- W3004613193 cites W2047405437 @default.
- W3004613193 cites W2048512322 @default.
- W3004613193 cites W2049422258 @default.
- W3004613193 cites W2050286493 @default.
- W3004613193 cites W2056587430 @default.
- W3004613193 cites W2057119643 @default.
- W3004613193 cites W2057652201 @default.
- W3004613193 cites W2058770491 @default.
- W3004613193 cites W2059282377 @default.
- W3004613193 cites W2061092924 @default.
- W3004613193 cites W2064233524 @default.
- W3004613193 cites W2065172786 @default.
- W3004613193 cites W2071325036 @default.
- W3004613193 cites W2071552652 @default.
- W3004613193 cites W2071729965 @default.
- W3004613193 cites W2073106255 @default.
- W3004613193 cites W2075458954 @default.
- W3004613193 cites W2078075583 @default.
- W3004613193 cites W2078498092 @default.
- W3004613193 cites W2081993846 @default.
- W3004613193 cites W2085966409 @default.
- W3004613193 cites W2089920619 @default.
- W3004613193 cites W2092738781 @default.
- W3004613193 cites W2095312765 @default.
- W3004613193 cites W2100017730 @default.
- W3004613193 cites W2100541589 @default.
- W3004613193 cites W2100819216 @default.
- W3004613193 cites W2103111028 @default.
- W3004613193 cites W2105447386 @default.
- W3004613193 cites W2107038434 @default.
- W3004613193 cites W2108984616 @default.
- W3004613193 cites W2109183032 @default.
- W3004613193 cites W2109427473 @default.
- W3004613193 cites W2112780227 @default.
- W3004613193 cites W2114762781 @default.
- W3004613193 cites W2115549161 @default.
- W3004613193 cites W2118086536 @default.
- W3004613193 cites W2118838698 @default.
- W3004613193 cites W2121025106 @default.
- W3004613193 cites W2126084304 @default.
- W3004613193 cites W2127811298 @default.
- W3004613193 cites W2128440410 @default.
- W3004613193 cites W2131871062 @default.
- W3004613193 cites W2141121840 @default.
- W3004613193 cites W2144175267 @default.
- W3004613193 cites W2145100181 @default.
- W3004613193 cites W2147039800 @default.
- W3004613193 cites W2150631640 @default.
- W3004613193 cites W2151487377 @default.
- W3004613193 cites W2154406573 @default.
- W3004613193 cites W2156340505 @default.
- W3004613193 cites W2156967983 @default.
- W3004613193 cites W2158683533 @default.