FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004679970> ?p ?o ?g. }

• W3004679970 abstract "Background: Allergic bronchopulmonary mycosis (ABPM) is an underestimated allergic disease due to fungi. Most reported cases are caused by Aspergillus fumigatus (Af) and are referred to as allergic bronchopulmonary aspergillosis (ABPA). The main risk factor of ABPA is a history of lung disease, such as cystic fibrosis, asthma, or chronic obstructive pulmonary disease. The main diagnostic criteria for ABPA rely on the evaluation of humoral IgE and IgG responses to Af extracts, although these cannot discriminate Af sensitization and ABPA. Moreover, fungi other than Af have been incriminated. Flow cytometric evaluation of functional responses of basophils and lymphocytes in the context of allergic diseases is gaining momentum. Objectives: We hypothesized that the detection of functional responses through basophil and lymphocyte activation tests might be useful for ABPM diagnosis. We present here the results of a pilot study comparing the performance of these cellular assays vs. usual diagnostic criteria in a cystic fibrosis (CF) cohort. Methods:Ex vivo basophil activation test (BAT) is a diagnostic tool highlighting an immediate hypersensitivity mechanism against an allergen, e.g., through CD63 upregulation as an indirect measure of degranulation. Lymphocyte stimulation test (LST) relies on the upregulation of activation markers, such as CD69, after incubation with allergen(s), to explain delayed hypersensitivity. These assays were performed with Af, Penicillium, and Alternaria extracts in 29 adult CF patients. Results: BAT responses of ABPA patients were higher than those of sensitized or control CF patients. The highest LST result was for a woman who developed ABPA 3 months after the tests, despite the absence of specific IgG and IgE to Af at the time of the initial investigation. Conclusion: We conclude that basophil and lymphocyte activation tests could enhance the diagnosis of allergic mycosis, compared to usual humoral markers. Further studies with larger cohorts and addressing both mold extracts and mold relevant molecules are needed in order to confirm and extend the application of this personalized medicine approach." @default.
• W3004679970 created "2020-02-14" @default.
• W3004679970 creator A5017474786 @default.
• W3004679970 creator A5022450409 @default.
• W3004679970 creator A5023248965 @default.
• W3004679970 creator A5031799252 @default.
• W3004679970 creator A5038313880 @default.
• W3004679970 creator A5050185568 @default.
• W3004679970 creator A5058570354 @default.
• W3004679970 creator A5059418171 @default.
• W3004679970 creator A5059466600 @default.
• W3004679970 creator A5073054824 @default.
• W3004679970 creator A5078536939 @default.
• W3004679970 creator A5089800716 @default.
• W3004679970 date "2020-02-07" @default.
• W3004679970 modified "2023-10-13" @default.
• W3004679970 title "Evaluation of Cellular Responses for the Diagnosis of Allergic Bronchopulmonary Mycosis: A Preliminary Study in Cystic Fibrosis Patients" @default.
• W3004679970 cites W1650397053 @default.
• W3004679970 cites W1689458960 @default.
• W3004679970 cites W1841670977 @default.
• W3004679970 cites W1897781703 @default.
• W3004679970 cites W1904704671 @default.
• W3004679970 cites W1933128164 @default.
• W3004679970 cites W1967172794 @default.
• W3004679970 cites W1976559973 @default.
• W3004679970 cites W198094254 @default.
• W3004679970 cites W2004772981 @default.
• W3004679970 cites W2011477740 @default.
• W3004679970 cites W2024799835 @default.
• W3004679970 cites W2039912716 @default.
• W3004679970 cites W2087094124 @default.
• W3004679970 cites W2091383650 @default.
• W3004679970 cites W2100544695 @default.
• W3004679970 cites W2108511018 @default.
• W3004679970 cites W2113009457 @default.
• W3004679970 cites W2115511578 @default.
• W3004679970 cites W2121659989 @default.
• W3004679970 cites W2133714677 @default.
• W3004679970 cites W2139627695 @default.
• W3004679970 cites W2141197648 @default.
• W3004679970 cites W2166365239 @default.
• W3004679970 cites W2271283846 @default.
• W3004679970 cites W2279521012 @default.
• W3004679970 cites W2282407471 @default.
• W3004679970 cites W2418916810 @default.
• W3004679970 cites W2556738553 @default.
• W3004679970 cites W2604810450 @default.
• W3004679970 cites W2626950978 @default.
• W3004679970 cites W2745612993 @default.
• W3004679970 cites W2769534242 @default.
• W3004679970 cites W2809304180 @default.
• W3004679970 cites W2884122311 @default.
• W3004679970 cites W2901872839 @default.
• W3004679970 cites W4241351653 @default.
• W3004679970 doi "https://doi.org/10.3389/fimmu.2019.03149" @default.
• W3004679970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7018936" @default.
• W3004679970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32117206" @default.
• W3004679970 hasPublicationYear "2020" @default.
• W3004679970 type Work @default.
• W3004679970 sameAs 3004679970 @default.
• W3004679970 citedByCount "7" @default.
• W3004679970 countsByYear W30046799702020 @default.
• W3004679970 countsByYear W30046799702021 @default.
• W3004679970 countsByYear W30046799702022 @default.
• W3004679970 crossrefType "journal-article" @default.
• W3004679970 hasAuthorship W3004679970A5017474786 @default.
• W3004679970 hasAuthorship W3004679970A5022450409 @default.
• W3004679970 hasAuthorship W3004679970A5023248965 @default.
• W3004679970 hasAuthorship W3004679970A5031799252 @default.
• W3004679970 hasAuthorship W3004679970A5038313880 @default.
• W3004679970 hasAuthorship W3004679970A5050185568 @default.
• W3004679970 hasAuthorship W3004679970A5058570354 @default.
• W3004679970 hasAuthorship W3004679970A5059418171 @default.
• W3004679970 hasAuthorship W3004679970A5059466600 @default.
• W3004679970 hasAuthorship W3004679970A5073054824 @default.
• W3004679970 hasAuthorship W3004679970A5078536939 @default.
• W3004679970 hasAuthorship W3004679970A5089800716 @default.
• W3004679970 hasBestOaLocation W30046799701 @default.
• W3004679970 hasConcept C126322002 @default.
• W3004679970 hasConcept C141105273 @default.
• W3004679970 hasConcept C151730666 @default.
• W3004679970 hasConcept C159654299 @default.
• W3004679970 hasConcept C203014093 @default.
• W3004679970 hasConcept C2776042228 @default.
• W3004679970 hasConcept C2776938444 @default.
• W3004679970 hasConcept C2778871687 @default.
• W3004679970 hasConcept C2779343474 @default.
• W3004679970 hasConcept C2779787849 @default.
• W3004679970 hasConcept C71924100 @default.
• W3004679970 hasConcept C86803240 @default.
• W3004679970 hasConceptScore W3004679970C126322002 @default.
• W3004679970 hasConceptScore W3004679970C141105273 @default.
• W3004679970 hasConceptScore W3004679970C151730666 @default.
• W3004679970 hasConceptScore W3004679970C159654299 @default.
• W3004679970 hasConceptScore W3004679970C203014093 @default.
• W3004679970 hasConceptScore W3004679970C2776042228 @default.
• W3004679970 hasConceptScore W3004679970C2776938444 @default.
• W3004679970 hasConceptScore W3004679970C2778871687 @default.
• W3004679970 hasConceptScore W3004679970C2779343474 @default.
• W3004679970 hasConceptScore W3004679970C2779787849 @default.

• next