FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004681808> ?p ?o ?g. }

• W3004681808 endingPage "67" @default.
• W3004681808 startingPage "67" @default.
• W3004681808 abstract "Tuberculosis (TB) is still an important global threat and although the causing organism has been discovered long ago, effective prevention strategies are lacking. Mycobacterium tuberculosis (MTB) is a unique pathogen with a complex host interaction. Understanding the immune responses upon infection with MTB is crucial for the development of new vaccination strategies and therapeutic targets for TB. Recently, it has been proposed that sensing bacterial nucleic acid in antigen-presenting cells via intracellular pattern recognition receptors (PRRs) is a central mechanism for initiating an effective host immune response. Here, we summarize key findings of the impact of mycobacterial RNA sensing for innate and adaptive host immunity after MTB infection, with emphasis on endosomal toll-like receptors (TLRs) and cytosolic sensors such as NLRP3 and RLRs, modulating T-cell differentiation through IL-12, IL-21, and type I interferons. Ultimately, these immunological pathways may impact immune memory and TB vaccine efficacy. The novel findings described here may change our current understanding of the host response to MTB and potentially impact clinical research, as well as future vaccination design. In this review, the current state of the art is summarized, and an outlook is given on how progress can be made." @default.
• W3004681808 created "2020-02-14" @default.
• W3004681808 creator A5019830762 @default.
• W3004681808 creator A5053887656 @default.
• W3004681808 date "2020-02-04" @default.
• W3004681808 modified "2023-10-01" @default.
• W3004681808 title "RNA Sensing of Mycobacterium tuberculosis and Its Impact on TB Vaccination Strategies" @default.
• W3004681808 cites W1479876200 @default.
• W3004681808 cites W1840987421 @default.
• W3004681808 cites W1964607061 @default.
• W3004681808 cites W1964701241 @default.
• W3004681808 cites W1985902878 @default.
• W3004681808 cites W1993442154 @default.
• W3004681808 cites W1996209042 @default.
• W3004681808 cites W2003301452 @default.
• W3004681808 cites W2015823325 @default.
• W3004681808 cites W2016132270 @default.
• W3004681808 cites W2020340820 @default.
• W3004681808 cites W2021530329 @default.
• W3004681808 cites W2023650245 @default.
• W3004681808 cites W2027265343 @default.
• W3004681808 cites W2040527513 @default.
• W3004681808 cites W2040928488 @default.
• W3004681808 cites W2041910415 @default.
• W3004681808 cites W2044757050 @default.
• W3004681808 cites W2045668077 @default.
• W3004681808 cites W2062782479 @default.
• W3004681808 cites W2063840218 @default.
• W3004681808 cites W2065031087 @default.
• W3004681808 cites W2074895894 @default.
• W3004681808 cites W2075442260 @default.
• W3004681808 cites W2075482744 @default.
• W3004681808 cites W2081496541 @default.
• W3004681808 cites W2090877072 @default.
• W3004681808 cites W2097072854 @default.
• W3004681808 cites W2101358576 @default.
• W3004681808 cites W2102364213 @default.
• W3004681808 cites W2109445380 @default.
• W3004681808 cites W2118194631 @default.
• W3004681808 cites W2119874060 @default.
• W3004681808 cites W2122638295 @default.
• W3004681808 cites W2125773632 @default.
• W3004681808 cites W2136886125 @default.
• W3004681808 cites W2136947275 @default.
• W3004681808 cites W2138822121 @default.
• W3004681808 cites W2148537541 @default.
• W3004681808 cites W2150107812 @default.
• W3004681808 cites W2151777859 @default.
• W3004681808 cites W2158235902 @default.
• W3004681808 cites W2161035695 @default.
• W3004681808 cites W2170320980 @default.
• W3004681808 cites W2185569673 @default.
• W3004681808 cites W2227385794 @default.
• W3004681808 cites W2259720540 @default.
• W3004681808 cites W2292714180 @default.
• W3004681808 cites W2303714942 @default.
• W3004681808 cites W2306114250 @default.
• W3004681808 cites W2330765795 @default.
• W3004681808 cites W2337907233 @default.
• W3004681808 cites W2367861527 @default.
• W3004681808 cites W2424055986 @default.
• W3004681808 cites W2485674081 @default.
• W3004681808 cites W2531189450 @default.
• W3004681808 cites W2539111758 @default.
• W3004681808 cites W2550734473 @default.
• W3004681808 cites W2553478620 @default.
• W3004681808 cites W2560104021 @default.
• W3004681808 cites W2560693982 @default.
• W3004681808 cites W2568695491 @default.
• W3004681808 cites W2576413724 @default.
• W3004681808 cites W2586427476 @default.
• W3004681808 cites W2588635729 @default.
• W3004681808 cites W2597394874 @default.
• W3004681808 cites W2600481111 @default.
• W3004681808 cites W2607252756 @default.
• W3004681808 cites W2608290060 @default.
• W3004681808 cites W2615474550 @default.
• W3004681808 cites W2750560136 @default.
• W3004681808 cites W2753051611 @default.
• W3004681808 cites W2753763137 @default.
• W3004681808 cites W2754462257 @default.
• W3004681808 cites W2760576414 @default.
• W3004681808 cites W2761118397 @default.
• W3004681808 cites W2763050565 @default.
• W3004681808 cites W2763570319 @default.
• W3004681808 cites W2768486282 @default.
• W3004681808 cites W2769106867 @default.
• W3004681808 cites W2769975546 @default.
• W3004681808 cites W2770426715 @default.
• W3004681808 cites W2771147459 @default.
• W3004681808 cites W2784170705 @default.
• W3004681808 cites W2789518147 @default.
• W3004681808 cites W2789533682 @default.
• W3004681808 cites W2789773364 @default.
• W3004681808 cites W2789931212 @default.
• W3004681808 cites W2790134490 @default.
• W3004681808 cites W2790184736 @default.
• W3004681808 cites W2790399997 @default.

• next